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Point/Counterpoint Editorials |

Rebuttal From Dr Rho et alRebuttal From Dr Rho et al

Jason Rho, MD; Nancy Ho, MD; Vinay Prasad, MD
Author and Funding Information

From the Department of Medicine (Dr Rho), Northwestern University; the Department of Medicine (Dr Ho), University of Maryland Medical Center; and the Medical Oncology Branch (Dr Prasad), National Cancer Institute, National Institutes of Health.

Correspondence to: Vinay Prasad, MD, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, 10/12N226, Bethesda, MD 20892; e-mail: vinayak.prasad@nih.gov


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(5):943-944. doi:10.1378/chest.14-0115
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Extract

We appreciate the thoughtful comments of Drs Suissa and Rabe.1 In many respects, regarding the specifics of the roflumilast trials, there is little disagreement. We concur with the authors that roflumilast has “rather frequent side effects, which have led to significant premature discontinuations in clinical trials.” A Cochrane meta-analysis confirms that patients receiving roflumilast are more likely to experience diarrhea, nausea, and headache and more likely to discontinue medication because of adverse events than patients receiving placebo.2 Nevertheless, there are some contrasts and clarifications worth noting.

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