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Challenges in Providing Critical Care for Patients With Anti-N-Methyl-d-Aspartate Receptor EncephalitisAnti-N-Methyl-d-Aspartate Receptor Encephalitis

Christopher M. Howard, MD; Joseph S. Kass, MD, JD; Venkata D. P. Bandi, MD, FCCP; Kalpalatha K. Guntupalli, MD, FCCP
Author and Funding Information

From the Pulmonary, Critical Care, and Sleep Section (Drs Howard, Bandi, and Guntupalli) and the Department of Neurology (Dr Kass), Baylor College of Medicine; and the Department of Neurology (Dr Kass) and the Medical Intensive Care Unit (Drs Bandi and Guntupalli), Ben Taub General Hospital, Houston, TX.

Correspondence to: Christopher M. Howard, MD, One Baylor Plaza, Mail Stop 620, Houston, TX 77030; e-mail: ch5@bcm.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(5):1143-1147. doi:10.1378/chest.13-1490
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Anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is characterized by a constellation of psychiatric, neurologic, autonomic, and cardiopulmonary manifestations. Although patients typically recover with appropriate treatment, they commonly require weeks to months of inpatient care, including prolonged stays in critical care units. This case series not only advocates for consideration of the disease in the appropriate context but also specifically highlights the distinct challenges intensivists encounter caring for patients with NMDARE. With a greater knowledge of the nuances and sequelae of NMDARE, critical care specialists will be better equipped to anticipate and manage the potentially life-threatening complications of the disease.


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