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Rapid FEV1 Decline, Early COPD, and Angiotensin-Converting Enzymes?COPD and Angiotensin-Converting Enzymes

Jadwiga A. Wedzicha, MD; Gavin C. Donaldson, PhD
Author and Funding Information

From the Centre for Respiratory Medicine, University College London.

Correspondence to: Jadwiga A. Wedzicha, MD, Centre for Respiratory Medicine, Royal Free Campus, University College London, Rowland Hill St, Hampstead, London, NW3 2PF, England; e-mail: w.wedzicha@ucl.ac.uk


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(4):671-672. doi:10.1378/chest.13-2696
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Extract

COPD is a progressive, chronic inflammatory disorder caused by exposure to noxious agents. The condition is associated with considerable heterogeneity and progressive disability leading to increased mortality. Measurement of FEV1 is key in establishing the diagnosis of COPD and assessing its severity both as a single measure or in multidimensional tools. Decreasing FEV1 has been associated with increased respiratory and cardiovascular mortality.1,2 The classic definition of COPD describes progressive FEV1 decline over time, but we now know that this measure is variable3,4 and affected by the development of COPD exacerbations.5 Studies have shown that patients with COPD may, indeed, show rapid decline in FEV1, decline similar to the normal population, or even no actual FEV1 decline over time.4

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