Critical Care |

Prognosis of Patients With Active Tuberculosis Requiring Intensive Care Unit FREE TO VIEW

Filiz Kosar, PhD; Pelin Uysal, PhD; Levent Dalar, PhD; Emel Eryüksel, PhD; Aybuke Kekecoglu, PhD; Turkay Akbas, PhD
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Yedikule Chest Diseases and Chest Surgery Hospital, Istanbul, Turkey

Chest. 2014;145(3_MeetingAbstracts):207D. doi:10.1378/chest.1923880
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SESSION TITLE: Critical Care

SESSION TYPE: Slide Presentation

PRESENTED ON: Saturday, March 22, 2014 at 04:15 PM - 05:15 PM

PURPOSE: Tuberculosis remains an important health problem. The aim of this study was to evaluate the clinical characteristics, prognoses and predictors of mortality of patients with pulmonary tuberculosis (TB) with acute respiratory failure (ARF). We conducted a retrospective observational study

METHODS: Patients with confirmed active tuberculosis admitted to ICU between May 2010 and October 2014 were identified and enrolled. Clinical, radiological and bacteriological data at admission and during hospital stay were recorded. A multivariate analysis was performed to identify the predictive factors for mortality.

RESULTS: A total of 35 TB patients (8 females, mean age 45 yrs) admitted to ICU were included. Mean Acute Physiology and Chronic Health Evaluation (APACHE) II score at admission was 17.00 ±7,7. 16 of 35 (45.7 %) patients died in the ICU in the first 30 days. 23 patients (65.7 %) required invasive mechanical ventilation. The reasons associated with ICU admission were massive hemoptysis in 3 patients, empyema in 2 patients , active tuberculosis and sepsis in nine patients, tuberculous meningitis in one patients and tuberculosis and/or pneumonitis in others. High APACHE II score and invasive mechanical ventilation use were significiantly associated mortality ( p= 0.04 ve p = 0,030).

CONCLUSIONS: These data indicate a high mortality of patients with tuberculosis requiring intensive care unit care and identifies associated risk factors.

CLINICAL IMPLICATIONS: Acute respiratory failure caused by pulmonary tuberculosis necessitating mechanical ventilation has a high mortality rate and poor prognosis

DISCLOSURE: The following authors have nothing to disclose: Filiz Kosar, Pelin Uysal, Levent Dalar, Emel Eryüksel, Aybuke Kekecoglu, Turkay Akbas

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