0
Obstructive Lung Diseases |

Are Pseudomonas aeruginosa Risk Factors Associated With Pseudomonas Acute Exacerbation of COPD?

Pedro Marcos, MD; Pilar Sanjuan, MD; Santiago Rodriguez-Segade, MD; Natalia Uribe-Giraldo, MD; Marina Blanco-Aparicio, MD; Isabel Otero, MD; Jorge Ricoy, MD; Hector Verea, MD; Marcos Restrepo, MD
Author and Funding Information

CHU A Coruña, A Coruña, Spain


Chest. 2014;145(3_MeetingAbstracts):356A. doi:10.1378/chest.1836146
Text Size: A A A
Published online

Abstract

SESSION TITLE: COPD Epidemiology & Physiology Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: European respiratory society (ERS) guidelines recommend to stratify patients with acute exacerbations of COPD (AECOPD) according to the presence or not of risk factors(RF) for Pseudomonas aeruginosa (PA). There is controversy regarding the need to empirically cover PA in clinical practice. Therefore a better understanding of the prevalence and RF for PA in hospitalized patients with AECOPD is critical in order to appropriately adhere to clinical practice guidelines. Aim: 1) Determine the prevalence of PA pathogens and PA risk RF in hospitalized patients with AECOPD; and 2) Assess the association of PA isolation and PA RF among hospitalized patients with AECOPD.

METHODS: Retrospective cohort study at a tertiary hospital at la Coruna, Spain in 2009. Inclussion:1) Age >40 years old, 2) former or active smokers (>10 ppk/years), 3) prior spirometry (FEV1/FVC<70), and 4) an admission diagnosis of AECOPD. Exclussion: radiological confirmation of pneumonia as the cause of the AECOPD. We assessed the following risk factors: 1) recent hospitalization, 2) frequent or recent administration of antibiotics, 3) FEV <30%, and 4) oral steroid use (>10 mg of prednisolone daily in the last 2 weeks). We performed descriptive statistics and assessed for associations with a p value <0.05 for statistical significant values

RESULTS: We identify a PA prevalence rate of 4.2% (n=6) among 143 subjects hospitalized with an AECOPD. The most common PA RF was “frequent or recent administration of antibiotics” (n=33[23%]), followed by severe COPD disease (n=17[12%]), oral steroid use (n=10[7%]), and recent hospitalization (n=3[2%]). PA AECOPD was not associated with frequent or recent administration of antibiotics (Odds ratio [OR] 3.6; 95% confidence interval [CI] 0.7-18.5, p=.13), severe COPD disease (OR 1.5; 95%CI .2-13.8, p=.7), oral steroid use (OR 2.8; 95%CI .3-27.0, p=.4) and recent hospitalization (OR 0, p>.05).

CONCLUSIONS: There is a low prevalence of PA among patients with AECOPD. Despite the common presence of PA risk factors, there is no association between risk factors and PA-AECOPD.

CLINICAL IMPLICATIONS: Despite the presence of PA risk factors is significative, a small percentage of them are infected with PA. So, at this moment it is difficult to rely only on this factors when deciding PA antibiotic coverage.

DISCLOSURE: The following authors have nothing to disclose: Pedro Marcos, Pilar Sanjuan, Santiago Rodriguez-Segade, Natalia Uribe-Giraldo, Marina Blanco-Aparicio, Isabel Otero, Jorge Ricoy, Hector Verea, Marcos Restrepo

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543