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Higher AHI Predicts More Exacerbations in Indian Patients With Bronchial Asthma With Overlap of Obstructive Sleep Apnea and Not Affected by PAP Therapy FREE TO VIEW

Mayuri Johari, MBBS; Karn Mehra, MBBS; Deepak Talwar, DM
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Metro Center for Respiratory Diseases, Noida, India

Chest. 2014;145(3_MeetingAbstracts):596A. doi:10.1378/chest.1835494
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SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: OSAS is an independent risk factor for asthma exacerbations and OSAS symptoms are more common in asthmatic patients than in the general population. This study correlates number of exacerbations with AHI in 24 stable asthmatics with overlap of OSA

METHODS: 24 stable patients’ of BA with overlap of OSA diagnosed on PSG, using or not using CPAP, attending outpatient clinic of Metro Centre for Respiratory diseases were retrospectively analysed for number of exacerbations in last one year using SPSS software.

RESULTS: 18 out of 24 patients were not using CPAP(75%). The average pre-bronchodilator FEV1, EPSS, AHI and number of exacerbations in the previous year in those using CPAP was 1.21L(SD=0.49), 5.83(SD=1.72), 19.93(SD=10.37), 1.66(SD=1.21) respectively; whereas for those not using CPAP therapy were 1.35L(SD=0.54), 8.61(SD=5.08), 22.40(SD=14.41) and 2.38(SD=0.91) respectively. Strong positive correlation was observed between number of exacerbations and AHI irrespective of being on treatment or not(r=0.845;P=0.034 in those using PAP therapy and r=0.687;P=0.002 in those not using PAP therapy).

CONCLUSIONS: Increased number of exacerbations were observed in patients with high AHI in Overlap syndrome, not affected by therapy.

CLINICAL IMPLICATIONS: Several western studies have shown an improvement in asthma symptoms after the initiation of CPAP. Our study showed a direct relationship between BA exacerbations and AHI, but has small number of patients in group using CPAP. Hence, further studies are required to see the effect of CPAP in these group of patients.

DISCLOSURE: The following authors have nothing to disclose: Mayuri Johari, Karn Mehra, Deepak Talwar

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