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A Substantial Difference in Etiology Between Prevalent and Incident Cases of Pulmonary Arterial Hypertension in Slovakia FREE TO VIEW

Milan Luknar, MD; Peter Lesny, MD; Eva Goncalvesova, MD
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National Cardiovascular Institute, Bratislava, Slovakia

Chest. 2014;145(3_MeetingAbstracts):520A. doi:10.1378/chest.1835258
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SESSION TITLE: Pulmonary Hypertension Posters I

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The etiological spectrum of pulmonary arterial hypertension (PAH) in Eastern European countries seems to be different from Western Europe. The reasons for this have not been explained. The aim was to describe the differences in the etiology between prevalent and newly diagnosed PAH cases in Slovakia, a Central-Eastern European country.

METHODS: The retrospective SlovPAH registry was established in 2010 and included 129 patients (40 men) treated for PAH in Slovakia from September, 2005 to September, 2009. This registry did not explicitly discriminate between prevalent and incident cases. 68 adult pts (17 men) were newly diagnosed with PAH at the National Cardiovascular Institute Bratislava from September 2005, to June 2012. Etiological composition of the two cohorts was compared.

RESULTS: Within the mixed cohort of the SlovPAH registry, 54% of patients had PAH associated with congenital heart disease (CHD), 27% idiopathic PAH, 11% PAH associated with connective tissue disease (CTD), 5% portopulmonary PAH, and 3% other PAH. In the single-centre incident PAH cohort, 55% pts had idiopathic PAH, 26% CTD-associated PAH, 12% CHD-associated PAH, 4% portopulmonary PH, and 3% other PAH.

CONCLUSIONS: There is a substantial difference in etiology between mixed prevalent and incident PAH cohort and exclusively incident PAH cohort in Slovakia. While an association with CHD dominates among prevalent cases, the spectrum of incident cases seems to be similar to large Western European registries. Relatively higher prevalence of CHD-associated PAH among prevalent cases probably results from limited availability of pediatric heart surgery in the past.

CLINICAL IMPLICATIONS: Exact and pre-specified criteria and further considerations are necessary when comparing the epidemiological data between individual countries.

DISCLOSURE: The following authors have nothing to disclose: Milan Luknar, Peter Lesny, Eva Goncalvesova

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