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Chest Infections |

Effects and Rationale of Micronutrients Supplementation in the Treatment of Smear Positive Pulmonary Tuberculosis Patients

S. M. Abdullah Al Mamun, MD
Author and Funding Information

Apollo Hospitals Dhaka, Dhaka, Bangladesh


Chest. 2014;145(3_MeetingAbstracts):134A. doi:10.1378/chest.1835239
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Abstract

SESSION TITLE: Tuberculosis Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The ancient killer Tuberculosis is one of the major health problem, caused by Mycobacterium tuberculosis. Globally about 2 billion people are infected , 8 million develop active diseases & 2 million die per year . Though modern treatment cures the patient within 6 months , this long duration of smear& culture conversion favors transmission & acquired drug resistance .Malnutrition a common association with TB puts a patient deficient in various micronutrient like vitamin A & zinc , unique to facilitate the

METHODS: A randomized, controlled, prospective study was carried in the, National institute of diseases of the chest & hospital , Dhaka, Bangladesh. Among 119 smear positive TB patients 111 patients had completed the study . 54 patient(group A) had received vitamin A& zinc supplements ,57(group B) did not . Lab investigation(HB%, ESR , CRP ,CXR) were carried out & clinical evaluation was made in each patients on arrival in the ward .Group A received CAT-1 anti TB +Vit-A(5000 iu/d) & Zinc(15mg/d). GroupB received only CAT-1 antiTB. After completion of intensive phase(2 months) further evaluation was made.

RESULTS: Radiological improvement , rise of HB%, fall of ESR & CRP were more in micronutrients group . Smear conversion( more in groupA) had statistically significant difference between two groups of patients (p<0.001).

CONCLUSIONS: Vitamin A & zinc supplementation in intensive phase reveals better result than no supplement .

CLINICAL IMPLICATIONS: We can recommand it for all sputum positivt cases .as a result contact will be benifited

DISCLOSURE: The following authors have nothing to disclose: S. M. Abdullah Al Mamun

No Product/Research Disclosure Information


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