Diffuse Lung Disease |

A Case of Rheumatoid Arthritis-Related Pulmonary Disease Treated With Rituximab FREE TO VIEW

Deirdre Fitzgerald, MBBCh; Michael Henry, MD
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Cork University Hospital, Cork, Ireland

Chest. 2014;145(3_MeetingAbstracts):232A. doi:10.1378/chest.1833551
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SESSION TITLE: ILD Case Report Posters I

SESSION TYPE: Case Report Poster

PRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Rheumatoid arthritis (RA) is commonly associated with serositis, including pleural effusions. This case demonstrates the benefit of using rituximab (RTX) in the treatment of this condition.

METHODS: A 50 year old female non smoker with long standing RA on immunosuppression was investigated for bilateral pleural effusions unresponsive to empiric TB treatment. She subsequently developed a pericardial effusion resulting in tamponade and required surgical intervention. Histology of pleural and pericardial biopsies on VATS was consistent with serositis.

RESULTS: She was treated with rituximab and improved dramatically.

CONCLUSIONS: Rituximab (RTX) is a chimeric monoclonal antibody with activity against CD20 expressed by B cells. Keir et al showed an improvement in outcomes with use of RTX as rescue therapy in patients with advanced pulmonary disease related to CTD . This is the first recorded case of life-threatening rheumatoid-related serositis responsive to RTX.

CLINICAL IMPLICATIONS: In cases of RA-related pleural or pericardial effusions and ILD, consideration should be given to treatment with RTX.

DISCLOSURE: The following authors have nothing to disclose: Deirdre Fitzgerald, Michael Henry

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