0
Diffuse Lung Disease |

A Case of Rheumatoid Arthritis-Related Pulmonary Disease Treated With Rituximab

Deirdre Fitzgerald, MBBCh; Michael Henry, MD
Author and Funding Information

Cork University Hospital, Cork, Ireland


Chest. 2014;145(3_MeetingAbstracts):232A. doi:10.1378/chest.1833551
Text Size: A A A
Published online

Abstract

SESSION TITLE: ILD Case Report Posters I

SESSION TYPE: Case Report Poster

PRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Rheumatoid arthritis (RA) is commonly associated with serositis, including pleural effusions. This case demonstrates the benefit of using rituximab (RTX) in the treatment of this condition.

METHODS: A 50 year old female non smoker with long standing RA on immunosuppression was investigated for bilateral pleural effusions unresponsive to empiric TB treatment. She subsequently developed a pericardial effusion resulting in tamponade and required surgical intervention. Histology of pleural and pericardial biopsies on VATS was consistent with serositis.

RESULTS: She was treated with rituximab and improved dramatically.

CONCLUSIONS: Rituximab (RTX) is a chimeric monoclonal antibody with activity against CD20 expressed by B cells. Keir et al showed an improvement in outcomes with use of RTX as rescue therapy in patients with advanced pulmonary disease related to CTD . This is the first recorded case of life-threatening rheumatoid-related serositis responsive to RTX.

CLINICAL IMPLICATIONS: In cases of RA-related pleural or pericardial effusions and ILD, consideration should be given to treatment with RTX.

DISCLOSURE: The following authors have nothing to disclose: Deirdre Fitzgerald, Michael Henry

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543