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Significance of Coexisting Venous Thromboembolism in Hospitalized Tuberculosis Patients FREE TO VIEW

Ahmadreza Moradi, MD; Azin Mohebi-Nejad, MD; Seyed-Mohammad Abooturabi, MD; Behzad Yaghoubi, MD; Shahrzad Shemirani, BS; Payam Tabarsi, MD; Neda Behzadnia, MD; Mehdi Esmaili-Khansari, MS; Mohammadreza Masjedi, MD; Ehsan Chitsaz, MD; Behnood Bikdeli, MD; Babak Sharif-Kashani, MD
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National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

Chest. 2014;145(3_MeetingAbstracts):138A. doi:10.1378/chest.1833155
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SESSION TITLE: Tuberculosis Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Tuberculosis (TB) remains a major health concern worldwide. Studies have shown an association between TB and venous thromboembolism (VTE); however, the significance of this association has not been investigated. Despite the increased risk of VTE among patients with TB, to our knowledge, the significance of in-hospital VTE in these patients has not been investigated. We sought to compare the risk factors profile and in-hospital outcomes of hospitalized patients with TB who had coexisting in-hospital VTE versus those who did not have coexisting VTE.

METHODS: We performed a retrospective case-control review of the medical records of hospitalized patients with TB at National Research Institute of Tuberculosis and Lung Diseases from January 2001 to January 2010. We identified hospitalized TB patients who suffered from in-hospital VTE and used a large group of hospitalized TB patients without coexisting VTE as the control group. Demographics, clinical characteristics, co-morbid conditions and treatment outcomes were determined and compared between the two groups.

RESULTS: Thirty-three TB patients with VTE were identified and compared with 453 randomly selected isolated TB controls. All of the TB-VTE patients had deep vein thrombosis, five of whom were also complicated by pulmonary embolism. Distribution of demographics and clinical co-morbidities were comparable in the two groups. None of TB-VTE patients had received thromboprophylaxis, as opposed to prophylaxis rate of 19% in the control group (P=0.007). Smear-positive TB was more frequently seen in TB-VTE patients (96.8% versus 79.1%, P=0.017). Hospital stay was significantly longer among TB-VTE patients compared with isolated TB patients (median [Interquartile range]: 34 [23-44] days versus 18 [12-30] days, P=0.001).

CONCLUSIONS: In-hospital VTE is associated with increased length of stay and mortality in TB patients. Thromboprophylaxis is widely underused among hospitalized TB patients

CLINICAL IMPLICATIONS: Appropriate VTE prophylaxis might reduce the rate of in-hospital VTE and mitigate the outcomes in hospitalized TB patients.

DISCLOSURE: The following authors have nothing to disclose: Ahmadreza Moradi, Azin Mohebi-Nejad, Seyed-Mohammad Abooturabi, Behzad Yaghoubi, Shahrzad Shemirani, Payam Tabarsi, Neda Behzadnia, Mehdi Esmaili-Khansari, Mohammadreza Masjedi, Ehsan Chitsaz, Behnood Bikdeli, Babak Sharif-Kashani

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