Pulmonary Physiology |

Exhaled Nitric Oxide and Exhaled Breath Temperature in Healthy Indian Subjects FREE TO VIEW

Pallavi Periwal, MBBS; Mayuri Johari, MBBS; Deepak Talwar, DM
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Metro Centre for Respiratory Diseases, Noida, India

Chest. 2014;145(3_MeetingAbstracts):460A. doi:10.1378/chest.1830225
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SESSION TITLE: Physiology/PFTs/Rehabilitation Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Fractional Nitric Oxide concentration in Exhaled Breath (FeNO) and Exhaled breath temperature (EBT) and being considered for evaluation of eosinophilic inflammation of the lower airways. We evaluated the relationship between these two markers in healthy Indian individuals.

METHODS: Thirty (n=30) healthy normal individuals with Nasal Symptom Score (NSS)<=2 and ACQ5 <=2 were made to perform Exhaled Breath Nitric Oxide (NO) analysis using HypairFeNO (Medisoft) to measure bronchial FeNO as per standard protocol for the procedure. After a gap of 2 hours, fifteen (n=15) of thirty participants performed EBT using X-Xalo, Delmedica, (Singapore). Pearson correlation coefficient was used to analyse the relationship between exhaled breath NO with EBT.

RESULTS: Bronchial FeNO had normally distributed observed data (F=0.001; p=971). 17 out of 30 (56.67%) participants were male. Mean FeNO for healthy population was 24.58+/-16.23 ppb with maximum being 26.4+/-16.86 ppb and minimum 22.39+/-16 ppb from three consecutive manoeuvres. There was no significant difference in the bronchial FeNO repetitions negating the washout effect of NO in healthy population .Bronchial FeNO was not affected by the gender (p= 0.287) and age (p= 0.613).Mean plateau temperature achieved during EBT was 33.3+/- 1.61 degree Celsius and mean time to achieve this was 309.47+/-113.1 seconds. However, bronchial FeNO was not significantly correlated with EBT (p=0.723 and p=0.682 respectively) Plateau temperature and time to reach that temperature was significantly correlated with age (r= -0.587; p=0.021 and r=0.514; p=0.05) and not by gender indicating that in normal subjects with age EBT decreases.

CONCLUSIONS: This study showed no significant correlation between bronchial FeNO and EBT in normal healthy Indian subjects, higher EBT at younger age indicates EBT to be adjusted for age.

CLINICAL IMPLICATIONS: As no correlation was found between bronchial FeNO and EBT in normal healthy adults, the same maybe applicable to adult asthmatics. Further studies are required to establish the correlation between FeNO and EBT in adult asthmatics.

DISCLOSURE: The following authors have nothing to disclose: Pallavi Periwal, Mayuri Johari, Deepak Talwar

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