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Pulmonary Physiology |

Relationships of Serum Heavy Metal Level With Lung Function Based on Korean National Health and Nutrition Examination Surveys IV-V FREE TO VIEW

Ah Young Leem, MD; Song Yee Kim, MD; Eun Young Kim, MD; Kyung Soo Jung, MD; Moo Suk Park, MD; Young Sam Kim, MD; Se Kyu Kim, MD; Joon Chang, MD; Ji Ye Jung, MD
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Yonsei University College of Medicine, Seoul, Republic of Korea


Chest. 2014;145(3_MeetingAbstracts):464A. doi:10.1378/chest.1826626
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Abstract

SESSION TITLE: Physiology/PFTs/Rehabilitation Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Heavy metal exposure may contribute to increased oxidative stress and inflammation in the lungs, resulting in tissue destruction manifesting clinically as obstructive lung disease (OLD). We aimed to evaluate the association of serum lead and cadmium concentration with lung function and prevalence of OLD.

METHODS: Pooled cross-sectional data from the Korea National Health and Nutrition Examination Survey 2008-2011 were used for this study. OLD was defined as an FEV1/FVC ratio < 0.7. Current smokers were defined as self-reported current smokers or those with measured serum cotinine ≥ 95 ng/mL.

RESULTS: Our study included 4,912 subjects in Korea. The mean (SD) lead levels in the OLD group were significantly higher in comparison with normal control subjects (3.12 [1.39] vs 2.60 [1.27]; P<0.001).Similarly, mean (SD) serum cadmium levels were significantly higher in the OLD group compared with the control group (1.35 [0.67] vs 1.22 [0.71];P<0.001). We also evaluated lung function stratified by serum lead and cadmiumquartiles. In comparison with subjects with a lead concentration < 1.86 μg/L (lowest quartile), the FEV1 and FEV1/FVC ratio were significantly higher than subjects of the other quartiles (P<0.001 for all comparisons). In comparison with subjects with a cadmium concentration < 0.74 μg/L (lowest quartile), the FEV1 and FEV1/FVC ratio were significantly higher in subjects of the other quartiles (P<0.001 for all comparisons). Upon adjusted analysis, there was no significant association between the prevalence of OLD and serum lead concentrations. On the other hand, in comparison with subjects with a cadmium concentrations < 0.74 μg/L (lowest quartile), the odds of OLD were significantly higher in subjects with cadmium concentrations ≥ 1.55μg/L (highest quartile) among smokers (OR, 1.60; 95% CI 1.08-2.39).

CONCLUSIONS: In a large representative sample of the Korea population, we demonstrated a significant association between FEV1/FVC ratio and serum lead and cadmium concentrations. The risk for OLD was related to serum cadmium concentrations.

CLINICAL IMPLICATIONS: It was the first study to evaluate the association of serum lead and cadmium concentration with lung function and prevalence of OLD.

DISCLOSURE: The following authors have nothing to disclose: Ah Young Leem, Song Yee Kim, Eun Young Kim, Kyung Soo Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Ji Ye Jung

No Product/Research Disclosure Information


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