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Analysis of Factors Associated With the Frequency of Exacerbations in Chronic Cough FREE TO VIEW

Carolina Gotera, MD; Carolina Jurkojc Mohremberger, MD; Adalberto Pacheco, PhD
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Ramon y Cajal Hospital, Madrid, Spain

Chest. 2014;145(3_MeetingAbstracts):569A. doi:10.1378/chest.1826407
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SESSION TITLE: Symptoms of Respiratory Disease Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The purpose of our work is to determine the profile of patients most likely to develop these episodes taking into account obstructive airway problems such as asthma or COPD as the most common and therefore investigated the airway eosinophilic inflammation (asthma type cough and eosinophilic bronchitis) as well as active smoking or the presence of chronic airflow obstruction (CAO).

METHODS: The cough type asthma diagnosis when chronic cougher history compatible with asthma and at least one positive physiological test: bronchial hyperresponsiveness with methacholine challenge, peak flow significantly Uncertainty or salbutamol bronchodilator test positive. Eosinophilic bronchitis is diagnosed by the presence of eosinophils in the sputum than 2% or more than 4% in BAL, plus a negative methacholine challenge. CAO also analyzed variables, current smoker and former smoker. The variable exacerbation of chronic cough is considered chronic when cougher reported experiencing greater presence of cough for at least 2 weeks with or without wheezing dyspnea, considered positive if there were 2 or more episodes per year.

RESULTS: In a series of 270 cases of chronic cough prospectively analyzed the airway eosinophilic inflammation was observed in 116 cases (80 type cough asthma, eosinophilic bronchitis, 25 and 11 do not eosinophilic bronchitis asthma), and when compared to the group without airway eosinophilic inflammation coughers, 72 cases, there was no significance in association with annual exacerbations of chronic cough. Comparing the group with non-CAO vs CAO association is significant for cough have more exacerbations per year in the CAO group, however we found no association between current smoking or having smoked to more exacerbations

CONCLUSIONS: The increased frequency of exacerbations of cough episodes per year in patients with chronic cough is associated with CAO not linked to smoking. Chronic cough phenotype linked to airway eosinophilic inflammationI not significantly related to cough more exacerbations per year, so it is necessary to investigate in the future, other phenotypes of chronic cough that link these events significantly worse quality of life in patients with chronic cough

CLINICAL IMPLICATIONS: there is a higher frequency of exacerbations of cough with or without wheezing dyspnea related to eosinophilic airway inflammation, smoking or OAD, so it may be difficult to control these parameters in order to avoid relapses .

DISCLOSURE: The following authors have nothing to disclose: Carolina Gotera, Carolina Jurkojc Mohremberger, Adalberto Pacheco

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