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Obstructive Lung Diseases |

Validation of a Disease Specific Severity Index for Non-Cystic Fibrosis Bronchiectasis: The BSI Index FREE TO VIEW

Melissa McDonnell, MMSc; James Chalmers, PhD; Pieter Goemmine, PhD; Stefano Aliberti, MD; Sara Lonni, MBChB; John Davison, MNSc; Lucy Poppelwell, MBChB; Walid Salih, MBChB; Alberto Pesci, MD; Lieven Dupont, PhD; Thomas Fardon, MD; Adam Hill, MD; Anthony De Soyza, PhD
Author and Funding Information

Lung Biology and Transplantation Group, Newcastle University, Newcastle, United Kingdom


Chest. 2014;145(3_MeetingAbstracts):428A. doi:10.1378/chest.1824434
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Abstract

SESSION TITLE: Bronchiectasis

SESSION TYPE: Slide Presentations

PRESENTED ON: Saturday, March 22, 2014 at 09:00 AM - 10:00 AM

PURPOSE: Non-cystic fibrosis bronchiectasis is a multicomponent disease associated with increased morbidity and mortality. Using data from 608 patients attending a specialist bronchiectasis clinic in Edinburgh, UK, the Bronchiectasis Severity Index (BSI) has recently been developed as a composite clinical prediction tool in bronchiectasis. The score consists of 8 commonly measured clinical parameters reflecting age, BMI, MRC dyspnoea score, FEV1%, bacterial colonisation, radiological extent, exacerbation frequency and prior hospitalization with subsequent classification into low, intermediate and high risk groups.

METHODS: Prospective observational studies of patients attending each of the four centres was performed. The utility of the BSI to predict mortality, hospital admission rates and exacerbation frequency across the three risk groups were determined in each cohort.

RESULTS: The validation cohorts totalled 702 patients; median age 65 years (interquartile range 56-74); 46% male. All-cause mortality was 2.3%, 13.5%, 16.6% and 1.9% in Scotland (n=251), England (n=126), Belgium (n=253) and Italy (n=105), respectively. The mortality and hospitalization rates increased with increasing BSI scores across all cohorts. The area under the receiver operator characteristic curve (AUC) for BSI-predicted mortality was 0.84 (Scotland), 0.82 (England) and 0.81 (Belgium). No AUC was calculated for Italy due to their minimal death rate. The AUC for BSI-predicted hospitalization rates was 0.82 (Scotland), 0.80 (England) and 0.88 (Italy) with no data for the Belgian cohort. The BSI predicted exacerbation frequency during follow-up in all cohorts where data was available (Scotland and England, p<0.001, Italy p=0.03). Meta-analysis data comparing results of derivation and validation cohorts (total 1315 patients) demonstrated that the score works consistently with low heterogeneity and high discriminatory ability.

CONCLUSIONS: The BSI is a reliable, valid, reproducible clinical prediction tool for calculating the probability of mortality, hospital admissions and exacerbation frequency in bronchiectasis.

CLINICAL IMPLICATIONS: The BSI score provides a much needed clinically useful outcome measure in bronchiectasis that may help risk-stratify patients and assist personalised medicines approaches.

DISCLOSURE: The following authors have nothing to disclose: Melissa McDonnell, James Chalmers, Pieter Goemmine, Stefano Aliberti, Sara Lonni, John Davison, Lucy Poppelwell, Walid Salih, Alberto Pesci, Lieven Dupont, Thomas Fardon, Adam Hill, Anthony De Soyza

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