Obstructive Lung Diseases |

NT-proBNP as Prognostic Biomarker in Patients With COPD Exacerbations and Respiratory Acidosis FREE TO VIEW

Elena Garcia Castillo, MD; Tamara Alonso Pérez, MD; Gonzalo Segrelles Calvo, PhD; Olga Rajas Naranjo, PhD; Enrique Zamora García, MD; Julio Ancochea, PhD
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Hospital Universitario La Princesa, Madrid, Spain

Chest. 2014;145(3_MeetingAbstracts):363A. doi:10.1378/chest.1824409
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SESSION TITLE: COPD Epidemiology & Physiology Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The aim of our study was to evaluated the capacity of NT-proBNP to identify high risk patients with COPD exacerbations.

METHODS: Pilot observational prospective study. We did the present study at the Hospital Universitario La Princesa (Madrid) in the period between 2012 may and 2013 may. We included 41 patients with COPD exacerbation and respiratory acidosis (pH<7,35 and PaCO2>45 mmHg) and needed of non-invasive mechanical ventilation. We did the following mesurements: 1.Clinical dates: spirometric values, previous COPD exacerbations, chronic oxygen therapy, comorbidities. 2.Laboratorie test. 3.NT-proBNP in the first 24th hours at the admission. 4.Complications during the income. 5.Death during the income. We classificated the patients into four groups according to the values of NT-proBNP: <500 pg/ml, 500-1.000 pg/ml, 1.000-5.000 pg/ml and >5.000 pg/ml.

RESULTS: 56% were men with about 76 years old. 25 patients had almost 2 exacerbations in the previous year. Patients with NT-proBNP>500 pg/ml had more probability of clinical complications during the income (more frequency cardiovascular one), more time of hospitalizations (13,3 vs 8,1 days), more death (7 vs 2), lower pH levels (7,26 vs 7,29) and higer PaCO2 levels (83,4 vs 70,6 mmHg).

CONCLUSIONS: NT-proBNP was a good biomarker in patients with COPD exacerbation and could difference a high risk group.

CLINICAL IMPLICATIONS: 1. Pre-selected a patients with poor prognostic. 2. Evaluated the implications of right ventricular function in the pathogenesis of the COPD exacerbation. 3. Evaluated news biomarkers in the COPD exacerbations.

DISCLOSURE: The following authors have nothing to disclose: Elena Garcia Castillo, Tamara Alonso Pérez, Gonzalo Segrelles Calvo, Olga Rajas Naranjo, Enrique Zamora García, Julio Ancochea

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