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Pulmonary Procedures |

The Role of EBUS-TBNA for the Diagnosis of Sarcoidosis

Rosa Cordovilla, PhD; Aldo Torracchi, MD; Gonzalo Varela Simó, PhD; Maria Asuncion Gomez, MD; José María González-Ruiz, PhD; Marcelo Fernando Jiménez López, PhD; Manuel Lanchas, MBBS; Miguel Barrueco, PhD
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Salamanca University Hospital, Salamanca, Spain


Chest. 2014;145(3_MeetingAbstracts):498A. doi:10.1378/chest.1824354
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Abstract

SESSION TITLE: Bronchoscopy & Interventional Procedures

SESSION TYPE: Slide Presentations

PRESENTED ON: Monday, March 24, 2014 at 09:00 AM - 10:30 AM

PURPOSE: Transbronchial and endobronchial biopsies are recommended as initial procedures for the diagnosis of pulmonary sarcoidosis. After emerging EBUS-TBNA, the diagnosis of indeterminate mediastinal lymph nodes with clinical suspicious of sarcoidosis might be challenging. In this report, we analyze the accuracy of EBUS-TBNA in the diagnosis of sarcoidosis and the influence of different factors in the diagnostic yield.

METHODS: We reviewed the cytopathologic reports of a series of 49 cases of benign Lymph nodes in which diagnosis was performed by EBUS. All patients had enlarged hilar and/or mediastinal LN in chest CT. We performed EBUS-TBNA under conscious sedation with 21 or 22 G needle and with or without ROSE. The gold standard was the histological study of lymph nodes made by mediastinoscopy if the results of EBUS-TBNA were negative.

RESULTS: EBUS-TBNA confirmed a diagnosis of sarcoidosis in 28 of the 49 patients (57%) by identifying non-caseating epitheliod cell granulomas. The remaining 21 patients were diagnosed by mediastinoscopy, 10 patients as sarcoidosis and 9 patients as non-specific benign LN. None of these patients had a high clinical suspicion of sarcoidosis. So, the diagnostic yield in patients with clinical suspicious of sarcoidosis was higher than in patients without it (66% vs 27%). The sensitivity of EBUS-TBNA was 74% and the diagnostic accuracy was 79%. ROSE did not improve the diagnostic yield but the results were better with 21G needle than with 22G needle (75% vs 54%). The mean size of the enlarged LN, as measured by EBUS, was 12.8 mm, and higher in sarcoidosis LN than non-sarcoidosis LN (15.3 mm vs 11.5 mm).

CONCLUSIONS: EBUS-TBNA is a useful tool for diagnosis of sarcoidosis and might be the first step in the diagnosis of sarcoidosis if hilar LN are present. The pre-test probability is an important influence in the diagnostic yield of EBUS for the diagnosis of sarcoidosis.

CLINICAL IMPLICATIONS: EBUS-TBNA may be considered to be a first procedure when the patient has suspected sarcoidosis with mediastinal lymph nodes.

DISCLOSURE: The following authors have nothing to disclose: Rosa Cordovilla, Aldo Torracchi, Gonzalo Varela Simó, Maria Asuncion Gomez, José María González-Ruiz, Marcelo Fernando Jiménez López, Manuel Lanchas, Miguel Barrueco

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