Obstructive Lung Diseases |

Pneumonia Among Patients Admitted for Acute Exacerbation of COPD in Penang, Malaysia FREE TO VIEW

Sana' AL Aqqad, RPh; Irfhan Ali Hyder Ali, MMed; Balamurugan Tangiisuran, PhD
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School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

Chest. 2014;145(3_MeetingAbstracts):359A. doi:10.1378/chest.1824346
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SESSION TITLE: COPD Epidemiology & Physiology Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: To evaluate the general and clinical characteristics of patients with and without coexistent pneumonia during admission for AECOPD.

METHODS: Clinical and demographic characteristics of 322 patients who were hospitalized in Penang General Hospital, Malaysia from 1st January 2007 till 31st December 2011 with primary diagnosis of AECOPD were evaluated retrospectively. Patients who died (n=63) during hospital stay were excluded due to incomplete information. All data including diagnosis of pneumonia were retrieved manually from patient medical records.

RESULTS: Of the total 259 patients [median age 70 (IQR= 59.7-76.7)] included in the study, only 69 (26.6%) were diagnosed with pneumonia. Patients with pneumonia were mainly male (85.5%). They have longer hospital stay (P=0.0014), high white blood cell counts (P=0.021) and temperature (P<0.001) on admission and high number of total comorbidities (P<0.001). Patients with pneumonia found to be highly prescribed with antibiotic during hospitalization as compared to non-pneumonia (98.6% vs. 70.5 %; P < 0.001). The use of diuretics, statins, gastrointestinal agents, and oseltamivir were significantly higher among pneumonic group during hospitalization. Significantly higher numbers of patients with pneumonia were discharged with diuretics as compared to non-pneumonia AECOPD patients (15.9% vs. 7.4%; P=0.040). Short term hospital readmission (30 days) were significantly higher among patients without the diagnosis of pneumonia as compared to pneumonia group (19.9% vs. 8.7%; P=0.048).

CONCLUSIONS: A quarter of hospitalization due to AECOPD was associated with secondary diagnosis of pneumonia. Patients in the pneumonia group have significantly longer hospital stay and were prescribed with high number of medications. Further exploration on the impact of pneumonia on humanistic outcomes among AECOPD patients is vital to improve patient care.

CLINICAL IMPLICATIONS: Patients admitted for AECOPD secondary to pneumonia should be monitored closely to reduce length of hospital stay and medication burden.

DISCLOSURE: The following authors have nothing to disclose: Sana' AL Aqqad, Irfhan Ali Hyder Ali, Balamurugan Tangiisuran

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