Obstructive Lung Diseases |

COPD Exacerbation: A Nine-Year Survival Study FREE TO VIEW

Daniel Coutinho, MD; Inês Franco, MD; Margarida Dias, MD; Maria Tzer, MD; Maria Brito, MD
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Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal

Chest. 2014;145(3_MeetingAbstracts):378A. doi:10.1378/chest.1821903
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SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The aim of our study was to look for the factors that affect survival of patients with COPD exacerbations admitted in a pulmonology department of a Portuguese central hospital.

METHODS: A retrospective nine-year study, where we included all the patients admitted with COPD exacerbations as a primary diagnosis between January 2004 and December 2012. Collected data included socio-demographic variables, smoking status and pack-years of smoking, pulmonary function tests, comorbidities and readmissions. Cox regression model was used to assess the influence of these variables on survival.

RESULTS: Three hundred and sixty three patients were included. Mean age 70,7±10,4 years, 84,8% were men and mean FEV1 42,5%±16,8. The 30-day readmission rate was 9,9% and the one-year all-cause mortality rate was 24,2%. In univariate analysis, we found a significant relationship between overall survival and age (p<0,001), gender (p=0,007), length of hospital stay (p=0,008), FEV1 (p<0,001), DLCO (p<0,001), pCO2 (p<0,001), smoking status (p=0,016), obesity (p=0,029) and GOLD stage (p=0,002). We haven’t found any relationship between pack-years of smoking, readmissions and some comorbidities, such as diabetes, hypertension and dyslipidemia. Ex-smoker status (p=0,001; HR=2,2) and increased GOLD stage (p=0,047; HR=1,5) had prognostic value on survival in our multivariate analysis.

CONCLUSIONS: Among patients admitted with COPD exacerbations, smoking status and GOLD stages were the main predictors of overall survival.

CLINICAL IMPLICATIONS: Despite the new COPD risk classes, apparently in clinical practice smoking status and degree of airflow obstruction should still be considered as important predictors of survival.

DISCLOSURE: The following authors have nothing to disclose: Daniel Coutinho, Inês Franco, Margarida Dias, Maria Tzer, Maria Brito

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