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Lung Cancer |

Volatile Organic Compounds (VOC) in Exhaled Breath in Patients With Lung Cancer

Javier Jareño, PhD; Maria Angeles Munoz, BScPharm; Carolin Wagner, MMed; Concepcion Civera, PharmD; Luis Callol, PhD
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Unidad de Investigacion - Hospital Central de la Defensa Gomez Ulla, Madrid, Spain


Chest. 2014;145(3_MeetingAbstracts):334A. doi:10.1378/chest.1821540
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Abstract

SESSION TITLE: Lung Cancer Posters I

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Oxidative stress is increased in lung cancer (LC) and generated volatile organic compounds (VOC). We can detect VOC in exhaled breath using the analytical technique Thermal desorber-gase cromatography and mass spectrometry (TD-GC/MS). The determination of VOC, may be useful as a noninvasive screening in LC. OBJETIVE: To determine differences in VOC present in the exhaled breath in 3 groups: LC group, COPD group and clinically healthy volunteers.

METHODS: Case-control study with 81 patients with LC, 40 patients with COPD and 89 healthy volunteers (without respiratory disease). Informed consent accepted. Collection of exhaled breath by means BioVOC (R) to functional residual capacity Analytical technique: TD-GC/MS (Markes-Agilent Tech.) We were anlyze 6 VOC (Aldehydes ande Carboxilic acids).Hexanal, Heptanal, Octanal; Nonanal, Propanoic Acid and Nonanoic Acid. Statistical analysis: SPSS® v-15 for Windows

RESULTS: Characteristics of study subjects: Control Group: n=89; 42 male (M) and 47 female (F). Age: 49(9.5). Smoker/exsmoker/non smoker: 30/24/25. Tobacco x year: 30(18) Smooker and EX36(24). COPD Group: n=40; 37(M) and 3(F). Age: 74(10). Smoker/exsmoker/non smoker: 34/6/0. Tobacco x year: 123(29) Smooker and EX 72(34) LC Group: n=81; 64(M) and 17(F). Age: 68(11). Smoker/exsmoker/non smoker: 52/22/9 . Tobacco x year: 77(50) Smooker and EX 63(24). The histology: Squamous Cells: 27; Adenocarcinoma: 39.5%,Undifferientiated: 18.5%, Large Cells - 2.5%; Small Cells: 11,5%; carcinoid: 1% TNM (IA/IB/IIA/IIB/IIIA): 53.10 (IIIB/IV): 46.9% LC+COPD:70.4; LC without COPD: 29.6% Nonanoic Ac presents statistical significance between LC vs Control; LC vs COPD.with p= 0.011 and p= 0.001respectively (Mann-Whitney Test). The Odds ratio (95% CI) based in logistic regression: LC vs. Control p= 0.011, LC vs. COPD: p=0.004

CONCLUSIONS: 1-Nonanoic acid is the only VOC with statistical significance between study groups: and it is independent of age and smoke custom. 2. - The probability to find nonanoic acid in LC group is higher than control and COPD groups 3. - Nonanoic acid could be useful to discriminate between LC + COPD patients versus LC without COPD patients. Supported by FIS: PI07/1116; Neumomadrid 2008 and SEPAR 2009/881. Neumomadrid 2012 and SEPAR 2013/135

CLINICAL IMPLICATIONS: VOCs in exhaled breath determination is a noninvasive procedure that can be helpful in the early diagnosis of lung cancer

DISCLOSURE: The following authors have nothing to disclose: Javier Jareño, Maria Angeles Munoz, Carolin Wagner, Concepcion Civera, Luis Callol

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