Sleep Disorders |

Relationship Between Type 2 Diabetes Mellitus and Obstructive Sleep Apnea Syndrome FREE TO VIEW

Doina Adina Todea, PhD; Paraschiva Postolache, PhD; Andreea Codruta Coman, PhD; Loredana Elena Rosca, PhD
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"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj Napoca, Romania

Chest. 2014;145(3_MeetingAbstracts):576A. doi:10.1378/chest.1799440
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SESSION TITLE: Comorbidities of OSA Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Type 2 diabetes mellitus (DM) and obstructive sleep apnea (OSA) share clinical outcomes being in this way a major public health concern. OSA may be under-recognised comorbidity of DM, so recent reports have indicated that the majority of patients with type 2 diabetes also have obstructive sleep apnea syndrome (OSA). The aim of the study was to evaluate the presence of diabetes mellitus between patients with obstructive sleep apnea syndrome.

METHODS: We examined 151 patients diagnosed to our Sleep Laboratory Center, between January to December 2012, with OSA by nocturnal cardio-respiratory poligraphy (apnea hypopnea index - AHI, oxygen saturation - SpO2, lowest SpO2, oxygen desaturation index - ODI being registered) and we screened all this patients for type 2 diabetes mellitus. Including criteria was cut-off value of ≥15 events/h according to the Apnea Hypopnea Index.

RESULTS: Ninety-nine patients (65.56%) had severe OSAS (≥30 events/h); 100 patients (66.22%) had type 2 diabetes mellitus (62 males, 38 females). The average of: apnea hypopnea index was 43.85±16.84; SpO2 average was 91.57±3.17; ODI was 36.75±10.85; lowest SpO2 was 74.20±13.82; body mass index was 36.41±7.26. Receiver operating characteristics (ROC) analysis reveals statistic significance for: age (p<0.01,AUC=0.69), neck circumference (p<0.01, AUC=0.67), abdominal circumference (p<0.01,AUC=0.70),BMI (p<0.01,AUC=0.70), glicemia (p=0.03,AUC=0.59), medium O2 saturation (p<0.01, AUC=0.70),oxigen desaturation index (p<0.01, AUC=0.63) and ESS (p=0.03, AUC=0.5). We found a statistically significant association between diabetes mellitus and OSA severity (p=0.037).

CONCLUSIONS: Type 2 diabetes mellitus is frequent between patients with obstructive sleep apnea, especially in moderate and severe forms of OSA.

CLINICAL IMPLICATIONS: Bidirectional relationship will be appropriate in clinical practice so, patients with type 2 diabetes mellitus should be screened for OSA and patients with OSA should also be evaluated for type 2 diabetes mellitus.

DISCLOSURE: The following authors have nothing to disclose: Doina Adina Todea, Paraschiva Postolache, Andreea Codruta Coman, Loredana Elena Rosca

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