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Lung Cancer |

Use of Desmosomal Plaque Related Proteins for Diagnosis of Non-small Cell Lung Cancer FREE TO VIEW

Mercedes Gomez-Morales, PhD; Miguel Camara-Pulido, PhD; Teresa Miranda-Leon, PhD; Abel Sanchez-Palencia, PhD; Laura Boyero, BS; Jose Antonio Gomez-Capilla, PhD; Esther Farez-Vidal, PhD
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School of Medicine. University of Granada, Granada, Spain


Chest. 2014;145(3_MeetingAbstracts):333A. doi:10.1378/chest.1790668
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Abstract

SESSION TITLE: Lung Cancer Posters I

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Immunohistochemistry is a highly valuable and widely used tool in the sub-typing of lung carcinomas, which would be assisted by the availability of lung-specific tumour markers. The importance of cell-cell junction proteins (including armadillo proteins) in tumour biology is known, but there is limited knowledge on specific intercellular adhesion proteins.

METHODS: We report on the immunohistochemical localization of plakophilin-1, keratin-15 and desmoglein-3 intercellular adhesion proteins in samples from 75 primary non-small cell lung cancers in non-treated patients.

RESULTS: The staining pattern of these proteins differed between squamous-cell carcinomas (SCC) and adenocarcinomas, with no membrane staining in the latter. Membrane staining by all three proteins was characteristic of squamous-cell carcinomas of the lung in our study. In squamous cell carcinomas, we observed a relationship between the presence/absence of these proteins in the membrane and the differentiation grade, with a more intense staining in better differentiated areas.

CONCLUSIONS: The staining pattern of these proteins differed between squamous-cell carcinomas (SCC) and adenocarcinomas, with no membrane staining in the latter. Membrane staining by all three proteins was characteristic of squamous-cell carcinomas of the lung in our study. In squamous cell carcinomas, we observed a relationship between the presence/absence of these proteins in the membrane and the differentiation grade, with a more intense staining in better differentiated areas.

CLINICAL IMPLICATIONS: Use of desmosomal plaque related protein for diagnosis of non-small cell lung cancer

DISCLOSURE: The following authors have nothing to disclose: Mercedes Gomez-Morales, Miguel Camara-Pulido, Teresa Miranda-Leon, Abel Sanchez-Palencia, Laura Boyero, Jose Antonio Gomez-Capilla, Esther Farez-Vidal

No Product/Research Disclosure Information


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