Diffuse Lung Disease |

The Unresolved Issue of Oxygen Therapy in Interstitial Lung Diseases: Some Clues From a Spanish Cohort FREE TO VIEW

Irene Martin, MD; Eva Balcells, MD; Amalia Moreno, PhD; Vanesa Vicens, MD; Ana Villar, MD; Alejandra Marin, MD; Esteban Cano, MD; Alejandro Robles, MD; Antonio Xaubet, PhD; Sergi Marti, PhD; Diego Castillo, MD; Maria Molina, PhD
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Hospital Universitari de Bellvitge, Barcelona, Spain

Chest. 2014;145(3_MeetingAbstracts):243A. doi:10.1378/chest.1781095
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SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: Indication of oxygen therapy in Interstitial Lung Diseases is not standardized and its specific requirements are not well defined. Objective: to evaluate Interstitial Lung Disease patients that requires ambulatory oxygen therapy.

METHODS: Clinical and exploratory data, including 6-minute walking test and Pulmonary Hypertension, from one hundred and seven patients with Interstitial Lung Disease who used ambulatory oxygen therapy were studied.

RESULTS: In up to 40% of cases the prescription of oxygen therapy was made after performing a 6-minute walking test. Patients who required ambulatory oxygen only during exercise presented a mild to moderate reduction of the predicted % FVC (62,1 ± 19) and DLCO (49 ± 14,4) while patients who had respiratory failure at rest (mean PaO2 51,9 ± 6,7) presented a moderate reduction of %FVC (56,8 ± 15,6) but a severe decrease of %DLCO (31,67 ± 12). PH was evaluated in 47.7% of patients and evidenced in 60.8% of them.

CONCLUSIONS: There is not a pulmonary functional predictor of oxyhaemoglobin desaturation during exercise. Pulmonary hypertension is frequently associated with interstitial lung diseases, mainly when respiratory failure at rest. The heterogeneity of these patients and limitation of retrospective studies could be the cause of the acknowledgment about the potential benefits of oxygen treatment in interstitial lung diseases.

CLINICAL IMPLICATIONS: Interstitial lung diseases are often associated with significant oxygen desaturation on exercise and with a high prevalence of associated Pulmonary Hypertension. However, few data and very low evidence are available in the oxygen treatment recommendation in Interstitial Lung Disease patients. The present study represents a review of the main features of these patients of a Spanish cohort and shows the specific oxygen requirements that Interstitial Lung Disease patients present and points up the relevance to test the potential benefits of an optimal oxygen therapy.

DISCLOSURE: The following authors have nothing to disclose: Irene Martin, Eva Balcells, Amalia Moreno, Vanesa Vicens, Ana Villar, Alejandra Marin, Esteban Cano, Alejandro Robles, Antonio Xaubet, Sergi Marti, Diego Castillo, Maria Molina

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