Disorders of the Pleura |

Sialic Acid Value in Pleural Effusion as a Diagnostic Marker of Malignancy FREE TO VIEW

Sherif Alsayed, MD; Samar Marzouk, MD
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NJCH, Jeddah, Saudi Arabia

Chest. 2014;145(3_MeetingAbstracts):276A. doi:10.1378/chest.1780685
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SESSION TITLE: Pleural Disease/Pleural Effusion Posters

SESSION TYPE: Poster Presentations

PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM

PURPOSE: The present study was designed to measure sialic acid levels in pleural effusion and serum samples of patients with malignant and nonmalignant diseases to discriminate each other, and to diagnose malignant effusion in a simple, cheap and reliable way.

METHODS: Sixty patients with pleural effusion were enrolled in the study and classified into two groups, group (I) 30 patients with malignant pleural effusion, and group (II) 30 patients with nonmalignant pleural effusion. Pleural fluid (PF) and serum (S) levels of sialic acid were measured prior to any therapy; and PF/S sialic acid ratios were calculated

RESULTS: Pleural fluid and serum levels of sialic acid were significantly higher in malignant group compared to nonmalignant one. PF/S sialic acid ratio was higher in malignant group compared to nonmalignant group. In the malignant pleural effusion group, smokers showed a statistically significant higher pleural fluid and serum sialic acid levels as compared to nonsmokers. By using ROC curve, the cut off value of malignant pleural fluid sialic acid was 69.65 mg/dL, sensitivity was 70%, and specificity was 96%.

CONCLUSIONS: These findings can approve the value of pleural fluid sialic acid as a promising marker for diagnosis of malignant pleural effusion.

CLINICAL IMPLICATIONS: Diaggnosis of malignant effusoin

DISCLOSURE: The following authors have nothing to disclose: Sherif Alsayed, Samar Marzouk

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