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A Case of Pulmonary Hemorrhage Due to Drug-Induced Pneumonitis Secondary to Ticagrelor TherapyTicagrelor-Induced Pulmonary Hemorrhage

Timothy J. Whitmore, MBBS (Hons); John P. O’Shea, MBBS; Diana Starac, MBBS; Mark G. Edwards, MBBS; Grant W. Waterer, MBBS
Author and Funding Information

From the Respiratory Medicine Department (Dr Whitmore), and Department of Cardiothoracic Surgery (Dr Edwards), Royal Perth Hospital, Perth; the Department of Cardiovascular Medicine (Dr O’Shea), Fremantle Hospital, Fremantle; Western Diagnostic Pathology (Dr Starac), Myaree; and the School of Medicine & Pharmacology (Dr Waterer), University of Western Australia, Perth, WA, Australia.

Correspondence to: Timothy J. Whitmore, MBBS (Hons), Respiratory Medicine, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6001; e-mail: timothy.whitmore@health.wa.gov.au


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(3):639-641. doi:10.1378/chest.13-1502
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We report a case of significant pulmonary hemorrhage developing shortly after commencing ticagrelor and aspirin therapy and requiring coronary artery bypass grafting to safely cease the antiplatelet therapy. Lung biopsy findings were consistent with drug-induced lung injury. Clinicians should be aware of this significant adverse event with this drug class.

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