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Ivan F. N. Hung, MD; Kwok-Yung Yuen, MD
Author and Funding Information

From the Department of Medicine (Dr Hung) and The Carol Yu Centre for Infection and Division of Infectious Diseases (Drs Hung and Yuen), State Key Laboratory of Emerging Infectious Diseases, Queen Mary Hospital, The University of Hong Kong.

Correspondence to: Ivan F. N. Hung, MD, Administrative Block 808, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong SAR, China; e-mail: ivanfn@gmail.com


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(2):435. doi:10.1378/chest.13-2617
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To the Editor:

We thank Dr Raschke for his comments on our article on hyperimmune IV immunoglobulin treatment.1 The subgroup analysis of the 22 patients who received treatment within 5 days of symptom onset was based on the fact that the viral load between the treatment and control arms became significantly different on day 5 from symptom onset (3.3 log10 copies/mL vs 4.67 log10 copies/mL, P = .04). We agree with Dr Raschke that there is a limitation in performing such a subgroup analysis, and we should have stated the plan to perform subgroup analysis according to the viral load result in the Materials and Methods section.

References

Hung IFN, To KKW, Lee C-K, et al. Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest. 2013;144(2):464-473. [CrossRef] [PubMed]
 

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References

Hung IFN, To KKW, Lee C-K, et al. Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest. 2013;144(2):464-473. [CrossRef] [PubMed]
 
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