Our unpublished data have revealed that of 35 patients who presented to our district hospital with APE diagnosed by multidetector CT pulmonary angiography, 15 underwent thrombolytic therapy (12 received alteplase and three received tenecteplase). The prethrombolysis SI in the patients submitted to thrombolysis was higher (0.94 ± 0.23) compared with those who were treated with standard anticoagulation using heparin (0.70 ± 0.20). After thrombolysis, the SI calculated using the highest recorded BP and simultaneous HR in the first 24 h decreased to 0.63 ± 0.11 (P < .0001, paired t test). The systolic BP values were not different before and after thrombolysis in the group (125 ± 19 mm Hg vs 126 ± 13 mm Hg, respectively), but HR was significantly decreased postthrombolysis (106 ± 18 beats/min vs 80 ± 15 beats/min, P < .0001). Irrespective of the index used, the two parameters provide indirect information on cardiac output, with tachycardia being a unifying feature of low-output states.