0
Editorials |

Lung-Gut Cross TalkLung-Gut Cross Talk: A Potential Mechanism for Intestinal Dysfunction in Patients With COPD

Simon Keely, PhD; Philip M. Hansbro, PhD
Author and Funding Information

From the Viruses, Infection, Immunity, Vaccine and Asthma (VIVA) Program, Hunter Medical Research Institute (HMRI); and School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.

Correspondence to: Simon Keely, PhD, School of Biomedical Science and Pharmacy, University of Newcastle, Callaghan, 2308, NSW, Australia; e-mail: simon.keely@newcastle.edu.au


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(2):199-200. doi:10.1378/chest.13-2077
Text Size: A A A
Published online

Extract

COPD describes a group of conditions that are characterized by loss of the functional capacity of the lungs, which is due to reduced and obstructed airflow.1 This disease exerts a large and increasing health burden worldwide and is often caused by exposure to tobacco smoking. Although primarily considered a respiratory disease, there is growing clinical interest in secondary organ manifestations of COPD, particularly in the GI tract. Indeed, GI disease is more prevalent in patients with COPD than in healthy populations.2 A population-based cohort study performed by Ekbom et al,3 showed a 2.72 times higher risk of Crohn’s disease (an inflammatory bowel disease) in COPD sufferers than that in healthy control subjects, greater than the risk reported for smoking alone. Specific intestinal complications include atrophic gastritis and nutritional absorption deficiency in the small intestine.4,5 Thus, there is a clear link between inflammatory diseases in the respiratory and intestinal systems. However, there have been surprisingly few research studies that have investigated the nature of the cross talk involved, and while several mechanisms have been proposed,6 to date there have been few studies that have aimed to elucidate these connections.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543