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Postgraduate Education Corner: Contemporary Reviews in Sleep Medicine |

Novel and Emerging Nonpositive Airway Pressure Therapies for Sleep ApneaNovel Therapies for Sleep Apnea

John G. Park, MD, FCCP; Timothy M. Morgenthaler, MD, FCCP; Peter C. Gay, MD, FCCP
Author and Funding Information

From the Mayo Clinic College of Medicine, Rochester, MN.

Correspondence to: John G. Park, MD, FCCP, 200 First Ave SW, Gonda 17W, Rochester, MN 55905; e-mail: park.john@mayo.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;144(6):1946-1952. doi:10.1378/chest.13-0273
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CPAP therapy has remained the standard of care for the treatment of sleep apnea for nearly 4 decades. Its overall effectiveness, however, has been limited by incomplete adherence despite many efforts to improve comfort. Conventional alternative therapies include oral appliances and upper airway surgeries. Recently, several innovative alternatives to CPAP have been developed. These novel approaches include means to increase arousal thresholds, electrical nerve stimulation, oral vacuum devices, and nasal expiratory resistive devices. We will review the physiologic mechanisms and the current evidence for these novel treatments.

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