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α1-Antitrypsin Deficiency03B11-Antitrypsin Deficiency: 50-Year Reflection: What Has It Ever Done for Us?

Robert A. Stockley, MD, DSc
Author and Funding Information

From the Lung Function and Sleep Department, ADAPT Project, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, England.

Correspondence to: Robert A. Stockley, MD, DSc, Lung Function and Sleep Department, ADAPT Project, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, England; e-mail: rob.stockley@uhb.nhs.uk


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;144(6):1923-1929. doi:10.1378/chest.13-1901
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The first five cases of α1-antitrypsin deficiency were originally published in 1963. This changed our whole concept about the pathophysiology of emphysema, including the role of inflammation and, in particular, the role of proteolytic enzymes. However, the observation also had a significant 50-year impact on many aspects of protein biochemistry, genetics, cell biology, and disease concepts outside the lung as well as the study of COPD in general.

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