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Original Research |

Do grandmaternal smoking patterns influence the aetiology of childhood asthma?

Laura L. Miller, MSc; John Henderson, MD; Kate Northstone, PhD; Marcus Pembrey, MD; Jean Golding, PhD
Author and Funding Information

School of Social and Community Medicine, University of Bristol, Bristol, UK (Miller, Henderson, Northstone, Pembrey, Golding)

Address for correspondence: Professor Jean Golding, Barley House, Oakfield Grove, Bristol BS8 2BN, UK; Email: jean.golding@bristol.ac.uk

Funding information: The statistical analyses for this project were undertaken with funding from the Medical Research Council [grant no. G1100226].


Chest. 2013. doi:10.1378/chest.13-1371
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Abstract

Background  Animal data suggest that tobacco smoke exposure of a mother when she is in utero influences DNA methylation patterns in her offspring and that there is an effect on the respiratory system, particularly airway responsiveness. The only study in humans suggests that there is a similar effect on asthma. The present study tests whether an association with respiratory problems can be confirmed in a large population study, and to determine whether in utero exposure of the father has similar effects on his offspring.

Methods  Information from the Avon Longitudinal Study of Parents and Children was used to compare the offspring of women and of men who had themselves been exposed to cigarette smoke in utero; separate analyses were performed for children of smoking and of non-smoking women. The outcome measures were: trajectories of history of early wheezing, doctor diagnosed asthma by seven years and results of lung function and methacholine challenge tests at eight years. A variety of social and environmental factors were taken into account; offspring sexes were examined separately.

Results  There was no association with any outcome in relation to maternal prenatal exposure. There was some evidence of an increase in asthma risk with paternal prenatal exposure when the study mother was a non-smoker: adjusted odds ratio [AOR] 1.17[95% CI 0.97,1.41]. This was particularly strong for girls (AOR=1.39[95% CI 1.04, 1.86]).

Conclusions  We did not find that maternal prenatal exposure to her mother’s smoking had any effect on her children’s outcomes tested. There was suggestive evidence of paternal prenatal exposure being associated with asthma and persistent wheezing in the grand-daughters.


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