Treatment consists of surgical removal or debulking of the thymoma. Patients with locally advanced-stage disease and/or metastatic disease may also require radiotherapy or combination chemotherapy. Removal of the tumor usually has favorable effects on the autoimmune disorders associated with Good syndrome, such as myasthenia gravis and pure red cell aplasia. Unfortunately, it does not seem to reverse the serum immunologic abnormalities, which can present months to years after tumor removal. Treatment with IV immunoglobulin is indicated in patients with hypogammaglobulinemia and can improve infection control and decrease hospitalizations. Bronchiectasis often develops because of recurrent sinopulmonary infections. Those who develop significant bronchiectasis should be followed closely by a chest physician and may require chronic treatments, such as postural drainage and prophylactic antibiotics, along with immunoglobulin replacement. The overall prognosis for Good syndrome remains worse than that for other immune deficiencies, with causes of death including infections, autoimmune disease, and hematologic complications. Patients requiring immunosuppression because of the presence of concomitant autoimmune disease usually have a more severe course.