In their counterpoint editorial, Drs Drewry and Hotchkiss1 present a well-reasoned argument of why fever may benefit those with life-threatening infections. We agree with several of their points that likely merit little further discussion:
1. Fever is an adaptive response and affords some host protection;
2. Little evidence-based support exists for use of antipyretic medications to improve fever-associated morbidity and/or mortality; and
3. Fever control in life-threatening infection merits further high-quality study.