Obstructive Lung Diseases |

Role of Diastolic Heart Dysfunction on Clinical Course in Patients With Acute COPD Exacerbation With Positive Pressure Ventilation Requirements FREE TO VIEW

Arseniy Tsapenko, MD; Patrick Barlow, MS; Michael McCormack, MD
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University of Tennessee Medical Center, Knoxville, TN

Chest. 2013;144(4_MeetingAbstracts):737A. doi:10.1378/chest.1705245
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SESSION TITLE: COPD Treatment Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Positive pressure ventilation (PPV) is being used as a standard rescue modality of lung ventilation in patients with respiratory failure secondary to COPD with acute exacerbation (COPDAE).We suspected that those patients with diastolic heart failure (DHF) in the settings of COPDAE with requirements to be on PPV have more complicated respiratory failure recovery course rather than those patients with no DHF. The purpose of this study was to evaluate if patients with DHF have longer hospitalization course compare to similar patient with no DHF .

METHODS: Patients, who were participated in this study, were selected as per study design criteria. All of these patients were admitted with COPDAE and required PPV were distributed in two groups with and without evidence of DHF on transthoracic ECHO. Descriptive statistic of study sample between DHF and no-DHF patient groups was performed, analyzed and compared.

RESULTS: 43 patients admitted with COPDAE who required to be on PPV were included in this study. 15 patients were in no-DHF group and 28 patients were in DHF group. Descriptive statistics of no-DHF and DHF groups were following: Female n(%)/Male n(%) : 8(58%)/ 7(42%) and 16(57%)/13(43%) respectively, age mean(SD) : 59.00( 7.98) and 63.39(8.05) respectively, days on PPV mean( SD) : 3.60 (2.20) and 4.65 (3.92) respectively.

CONCLUSIONS: There was observed a difference in lengths of stay on PPV between patients admitted for COPDAE with PPV requirement with and without DHF diagnosed on TTE. This finding was only based on descriptive statistics data of small group of patient. In order to statistically proof the difference in days on PPV - larger sample study is to be conducted.

CLINICAL IMPLICATIONS: Patients with DHF who were admitted with COPDAE with PPV requirement will probably spend longer time on PPV before their respiratory status improves compare to patients who have no-DHF.

DISCLOSURE: The following authors have nothing to disclose: Arseniy Tsapenko, Patrick Barlow, Michael McCormack

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