0
Chest Infections |

Outcomes of HIV Positive Patients Hospitalized With Pneumocystis jirovecii Pneumonitis

Ragai Meena, MD; Gulshan Sharma, MPH; George Samuel, MD
Author and Funding Information

UTMB, Galveston, TX


Chest. 2013;144(4_MeetingAbstracts):251A. doi:10.1378/chest.1704958
Text Size: A A A
Published online

Abstract

SESSION TITLE: AIDS/ Immunocompromised Patients Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Pneumocystis jirovecii pneumonitis is a serious opportunistic infection in HIV positive patients. Prior studies on outcomes of PJP patients were done over a decade. We examined the outcomes of HIV patients with PJP in the current era.

METHODS: Between January 2007 and August 2012, 119 HIV positive patients were discharged with primary or secondary discharge diagnoses of PJP based on International Classification of Disease (ICD)-9 codes 042 and 1363. We included patients with a confirmed PJP infection by sputum and/or BAL cytology. Data on baseline demographics, HIV viral load, CD-4 count, LDH levels, ICU admission, and receipt of mechanical ventilation, treatment with steroids, hepatitis-C co-infection, and presence of pneumothorax were recorded. A positive case of CMV was defined as any positive serological or BAL fluid by shell vial cultures, PCR, CMV IgG and/or IgM antibodies. Our primary outcome was in-hospital mortality. Descriptive statistics were presented as proportions and percents. T-test and chi square is used to compare continuous and categorical data, respectively. A p-value of<0.05 is consider statistical significant.

RESULTS: Fifty-seven patients had a confirmed diagnosis of PJP. All cause in-hospital mortality rate was 19%.There was no difference in CD-4 count, HIV viral load, total leukocytic count, serum LDH levels, HCV co-infection in those who died vs. those who survived. 18 patients (31%) had CMV co-infection. Patients with CMV co-infection had a higher mortality (27% vs.15%). Patients who died were more likely to have had respiratory failure and require mechanical ventilation.

CONCLUSIONS: Overall mortality among HIV positive patients with PJP pneumonitis remains high.

CLINICAL IMPLICATIONS: 1-Even after more than a decade,mortality from PJP pneumonitis in HIV patients remains high 2-Patients with CMV co-infection had a higher mortality (27% vs.15%), although not statistically significant

DISCLOSURE: The following authors have nothing to disclose: Ragai Meena, Gulshan Sharma, George Samuel

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543