Sleep Disorders |

Nocturnal Arrhythmias Associated With Obstructive Sleep Apnea Syndrome: Polysomnographic Evidence FREE TO VIEW

Paraschiva Postolache, PhD; Verona Mihai, PhD; Gianina Luca, MD; Doina-Adina Todea, PhD; Oana Arghir, PhD; Oana Deleanu, PhD; Roxana Maria Nemes, PhD; Cristina-Maria Gavrilescu, PhD
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"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

Chest. 2013;144(4_MeetingAbstracts):998A. doi:10.1378/chest.1704700
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SESSION TITLE: Sleep Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Hypoxemia, sleep arousals and sympathetic nervous system disturbances may trigger the development of arrhythmias during the night in patients with obstructive sleep apnea syndrome (OSA). Due to the multifactorial cause of arrhythmias in these patients, a complete profile of arrhythmic events during the night is yet missing. The aim of this study is to characterize the arrhythmias development in diagnosed OSA patients versus control group matched for age, gender, body mass index (BMI) and comorbidities and to evaluate the interaction between the severity of OSA and different types of arrhythmias.

METHODS: We report an observational case-control study (case: n=52; control: n=51). All participants underwent a full night polysomnography and were investigated for cardiovascular and metabolic disorders. Epochs preceding and following cardiac events were evaluated for changes in EEG pattern and frequency.

RESULTS: Sleep efficiency (case vs control: 83.8±12.4 vs 86±17) and slow wave sleep amount (22.4±11.6 vs 27±18) were significantly decreased in OSA patients. OSA represents a significant risk for development of arrhythmias during the night (OR 2.41, p=0.02). The best predictors for supraventricular arrhythmias were apnea-hypopnea index (AHI) and BMI (Rsqr=0.451, p<0.001), and for ventricular arrhythmias was only AHI (Rsqr=0.408, p<0.001). In NREM sleep arrhythmic events are preceded or develop in the same time with a spontaneous arousal, characterized by increase in EEG frequency.

CONCLUSIONS: Identification of specific changes in EEG before development of cardiac events might be useful for understanding the mechanism of arrhythmias which are not triggered by a respiratory event.

CLINICAL IMPLICATIONS: Prevention and detecting the causes of nocturnal arrhythmias in patients with obstructive sleep apnea.

DISCLOSURE: The following authors have nothing to disclose: Paraschiva Postolache, Verona Mihai, Gianina Luca, Doina-Adina Todea, Oana Arghir, Oana Deleanu, Roxana Maria Nemes, Cristina-Maria Gavrilescu

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