Sleep Disorders |

Gender Peculiarities in an Obstructive Sleep Apnea Population FREE TO VIEW

Oana Deleanu, PhD; Diana Pocora, MD; Florina Prunescu, MD; Paraschiva Postolache, PhD; Stefan Mihaicuta, PhD; Florin Mihaltan, PhD
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University of Medicine and Pharmacy Carol Davila, Bucharest, Romania

Chest. 2013;144(4_MeetingAbstracts):1002A. doi:10.1378/chest.1704396
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SESSION TITLE: Sleep Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: The difference between men and women suffering from obstructive sleep apnea syndrome (OSAS) represents a matter of debate, especially regarding the factors influencing these peculiarities. The authors aimed to analyze gender peculiarities encountered in an OSAS population.

METHODS: We analyzed retrospectively 284 OSAS patients who underwent sleep studies (poligraphy and polisomnography) and compared 230 (81%) male with 54 (19%) female. We used SPSS 17 software for the statistical analysis (Chi test, T student test, Pearson Correlation coefficient).

RESULTS: Men were significantly younger than women (47.7±12.1 vs 55.2±9.9 years, p<0.001), and accused nocturnal dyspnea (79.62% vs 62.17%, p=0.01). Women complained more about daytime sleepiness (66.6% vs 25.21%, p<0.001) without objective confirmation (Epworth sleepiness scale, p=NS), fatigue (77.7% vs 63.47%, p=0.03) and lack of attention (72.22% vs 46.9%, p=0.001) and morning headaches (64.81% vs 10%, p<0.001). When analyzing the population who underwent polisomnography (52 patients), we noticed that men have higher sleep latency (20.69±19.87 vs 10.22±9.61 min, p=0.02). There were no differences in terms of body mass index and smoking habit. Regarding comorbidities, women associated more frequently arterial hypertension, ischaemic heart disease, diabetes and endocrine disorders (all p<0.05). Sleep studies showed that men had significantly higher apnea-hypopnea index (AHI=48.6±33.3 vs 33.4±21.6/h, p=0.002) with more obstructive events and higher desaturation index (54.4±27.4 vs 38.3±24/h, p<0.001) but AHI correlates in an inverse manner with age(r= -0.28,p<0.001). There were no differences regarding the arousal index, percent of sleep stage or minimum SaO2. Out of 210 patients auto-CPAP titrated, 113 (53.8%) experienced failure (AHI>15/h). There were no significant differences between gender groups regarding titration failure and CPAP pressure.

CONCLUSIONS: Subjective somnolence was more expressed in women while men had lower quality of sleep. Despite other literature findings, we found gender differences only regarding AHI which is related to the age difference.

CLINICAL IMPLICATIONS: Understanding the influence gender has on OSA might lead to a better evaluation and treatment of disease.

DISCLOSURE: The following authors have nothing to disclose: Oana Deleanu, Diana Pocora, Florina Prunescu, Paraschiva Postolache, Stefan Mihaicuta, Florin Mihaltan

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