Sleep Disorders |

Severity of Obstructive Sleep Apnea Correlates With 25-Hydroxyvitamin-D Levels in Obese Asian Indian FREE TO VIEW

Yogendra Singh, PhD; Randeep Guleria, DM; N. Vikram, MD; S. Vivekanandhan, PhD
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All India Institute of Medical Sciences, Delhi, India

Chest. 2013;144(4_MeetingAbstracts):986A. doi:10.1378/chest.1704280
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Tuesday, October 29, 2013 at 02:45 PM - 04:15 PM

PURPOSE: Obstructive sleep apnea (OSA) and 25-hydroxyvitamin-D (25-OH-D) deficiency are two disorders associated with obesity, inflammation and myopathies. We hypothesized that low vitamin -D levels could correlate with the severity of OSA. We looked for correlation, if any, between serum 25-OH-D levels and severity of OSA as assessed by the apnea-hypopnea index (AHI).

METHODS: We studied 79 obese (BMI >25 Kg/m2) subjects (63 male with 16 female) with mean age of 46.6 years with suspected sleep disorders by Epworth sleepiness Scale. All subjects underwent a full-montage digital polysomnography. Demographic data and blood sample were collected. Serum level of 25-OH- D was evaluated in all patients. Subjects with AHI >5/h were diagnosed with OSA. Subject with 25-OH-D levels <10 ng/ml, 10-30 ng/ml and > 30 ng/ml was diagnosed as vitamin-D3 deficient, insufficient and sufficient respectively.

RESULTS: In the 79 obese subjects, we found 33 subjects had severe, 7 subjects had moderate, 13 subjects had mild OSA and 26 subjects did not have OSA. Overall 25-OH- D was deficient in 64.1% obese subjects with OSA. In 22 subjects with severe OSA, 5 subjects with moderate OSA, 7 subjects with mild OSA and 11 subjects without OSA, 25-OH-D was deficient. In 40 subject with moderate to severe OSA, the mean serum 25 OH-D levels was 12.94 ng/ml while in 39 subject with mild OSA, the mean serum 25-OH-D levels was 17.9 ng/ml. Chi square linear trend between AHI >15/h and 25-OH-D was 0.043.

CONCLUSIONS: Patients with more severe of OSA showed an increasing degree of 25-OH-D deficiency. A larger study is needed to confirm these findings.

CLINICAL IMPLICATIONS: Subjects with moderate to severe OSA should be evaluated for the vitamin D deficiency & treatment as this may help in reducing inflammation, and providing cardiovascular risk reduction.

DISCLOSURE: The following authors have nothing to disclose: Yogendra Singh, Randeep Guleria, N. Vikram, S. Vivekanandhan

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