0
Critical Care |

Role of Serum Procalcitonin as a Prognostic Biomarker in Community Acquired Pneumonia

Sudhir Agarwal, MD; Arvind Mishra, MBBS
Author and Funding Information

Institute of Medical Sciences, Varanasi, India


Chest. 2013;144(4_MeetingAbstracts):388A. doi:10.1378/chest.1704209
Text Size: A A A
Published online

Abstract

SESSION TITLE: ICU Infections Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Despite several studies, role of initial Procalcitonin (PCT) levels as a predictor of prognosis in the course of Community Acquired Pneumonia (CAP) remains somewhat undefined. Purpose of the present study was to analyse relationship between initial PCT levels and existing predictive scores in terms of final outcome of the disease.

METHODS: Fifty patients who received the diagnosis of CAP throughout the period of study were enrolled and examined comprehensively.Blood samples were collected.Microbiological tests done.Initial quantitative PCT levels and CRP levels were obtained.PCT levels were measured by commercially available monoclonal immunoluminometric assay(limit of detection 0.1microg/L).Patients were classified according to Pneumonia Severity Index (PSI ) and CURB-65 scores.PCT levels were compared among stratified risk groups.

RESULTS: Pathogens were identified in 26 patients(52%) and 16 (32%) had streptococcal pneumonia. Four out of 50 pts(8%) died.Three patients(6%) developed complications (pleural effusion) and PCT levels were higher in pneumococcal pneumonia. Multivariate regression analysis was done.Area under curve(AUC) for predicting mortality for CRP was ( 0.65,95% CI),for PCT was (0.81,95%CI),for CURB-65 was (0.88,95%CI)and for PSI score was (0.94,95%CI).AUC was highest for PSI and lowest for CRP.PCT levels strongly correlated with PSI and CURB-65 scores.PCT levels were higher in PSI classes 3 -5 (p = 0.01) and complications(p=0.03).

CONCLUSIONS: Serum Procalcitonin can be used as an adjuvant to already existing scores. It is more useful in predicting the outcome of CAP in high risk patients. It's superior to CRP but still can not replace the PSI and CURB -65 scores.

CLINICAL IMPLICATIONS: Serum Procalcitonin may be used as a prognostic biomarker in Community Acquired Pneumonia

DISCLOSURE: The following authors have nothing to disclose: Sudhir Agarwal, Arvind Mishra

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543