SESSION TITLE: Cystic Fibrosis/ Bronchiectasis Posters
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM
PURPOSE: The characteristic features of bronchiectasis are abnormal dilated thick-walled bronchi that are inflamed and chronically infected by bacteria. It is a chronic condition, which can result in significant physical and social morbidity. Adults with bronchiectasis often have chronic cough and sputum production and frequently develop pulmonary exacerbation driven by infection. The purpose of current study was to evaluate the long-term consequence of bronchiectsis patients.
METHODS: We enrolled 79 bronchiectasis patients who visited our institution and were followed up at least 1 year. There were 52 women and 27 men included in our study. The mean age was 60.1 years of age (range 35-86 years). All of the subjects were confirmed to have bronchiectasis by the chest CT scans.
RESULTS: The mean follow-up duration was 66.1±24.0 months. During the follow-up period, a total 46.8% of the patients admitted hospital and the total number of admission was 114. Among the patients who admitted hospital, the mean frequency of hospital admission was 3.08±2.08. Pneumonia was the most common cause of hospital admission (54.4% of the total admission). A total 37.7% of the admissions were due to acute exacerbation. The mean age of the patients who admitted hospital was older than patients who did not (65.0±12.1 vs. 55.8±12, p=0.001). The mean number of hospital admission according to the baseline pulmonary function was significantly different (0.33±0.76 in patients with normal pulmonary function; 1.57±2.51 in patients with restrictive defect; 0.60±0.89 in GOLD 1 patients; 1.22±1.86 in GOLD 2 patients; 3.87±4.03 in GOLD 3&4 patients , p<0.001). We cultured sputum samples for microbiology during the follow-up period. A total 55.7% of patients showed microbes in the sputum samples. Pseudomonas aeruginosa was the most frequently cultured pathogen (21.5%). Non tuberculosis mycobacterium was cultured in 13.9% of the patients. Patients with positive culture for P.aeruginosa admitted more frequently (3.41±3.91 vs.0.90±1.60, p<0.001).
CONCLUSIONS: A total 46.8% of bronchiectasis patients admitted hospital during the long-term follow-up period. Older patients with poor lung function and positive culture for P.aeruginosa experienced more hospital admission.
CLINICAL IMPLICATIONS: A more specific management strategy is needed for older non-cystic fibrosis bronchiectasis patients with poor lung function and positive culture for P.aeruginosa
DISCLOSURE: The following authors have nothing to disclose: Yong Il Hwang, Jee Hee Kim, Sunghoon Park, Seung Hun Jang, Yong Bum Park, Dong-Gyu Kim, In-Gyu Hyun, Myung-Goo Lee, Ji-Suck Jung
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