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Lung Cancer |

Lung Cancer in Nonsmoker Women: Clinical and Survival Patterns

Ricardo Duarte, MD; Andreia Monteiro, MD; Mauro Zamboni, MD
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Instituto Nacional de Cancer, Rio de Janeiro, Brazil


Chest. 2013;144(4_MeetingAbstracts):653A. doi:10.1378/chest.1703770
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Abstract

SESSION TITLE: Lung Cancer Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: To verify clinical, epidemiological and survival characteristics in a sample of Brazilian non-smoker women with diagnosis of primary lung cancer (LC).

METHODS: A historical cohort of non-smoker women with LC who were managed from 2000 to 2009 in a tertiary hospital of malignant disease located in Rio de Janeiro, Brazil. A statistical analysis was obtained with Mann-Whitney U test. Univariate probability of survival was computed using Kaplan-Meier estimate and compared using the log-rank test. A p < 0.05 indicated statistical significance and all reported p values are two-tailed.

RESULTS: A total of 143 women were studied (median age = 65.0 years). The most common histological type was adenocarcinoma (65.7%), followed by non-small cell lung cancer (13.3%), and squamous cell carcinoma (12.6%). The majority of the patients had advanced staging at diagnosis: stage IV in 50.4%, stage IIIB in 17.1%, and stage IIIA in 17.0%. The family history of cancer was positive in 41.9%. Concerning performance status (PS), PS 1 (57.3%) and 2 (21.4%) were the most common. In relation to treatment, 12 patients were treated with surgery and 131 patients were managed with non-surgical treatment or palliative care. The overall 1-year, 3-year and 5-year survival rates were, respectively: 34.5%, 9.9%, and 5.6%. The overall median survival was 8.7 months, in the surgical group was 51.8 months, and in the non-surgical group was 8.7 months (p < 0.0001). The 5-year survival rate was higher among women with non-adenocarcinoma histology than women with adenocarcinoma, although this difference was not significant (p = 0.263).

CONCLUSIONS: In a 10-year period, in a sample of non-smoker women with LC, we found a clear predominance of adenocarcinoma and advanced staging of disease. There was a low survival rate associated with a large difference on survival in relation to the treatment offered.

CLINICAL IMPLICATIONS: These data underscores the importance of early diagnosis of LC in non-smoker women.

DISCLOSURE: The following authors have nothing to disclose: Ricardo Duarte, Andreia Monteiro, Mauro Zamboni

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