Pulmonary Physiology |

Efficacy of Yoga on Inflammatory Markers, Dyspnea, and Quality of Life in COPD FREE TO VIEW

Sneh Arora, PhD; Randeep Guleria, DM; Guresh Kumar, PhD; Shiv Lal Yadav, MD; Anant Mohan, MD
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All India Institute of Medical Sciences-Department of Pulmonary Medicine and Sleep Disorders, New Delhi, India

Chest. 2013;144(4_MeetingAbstracts):787A. doi:10.1378/chest.1703685
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SESSION TITLE: Lung, Exercise and Aging

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, October 27, 2013 at 10:45 AM - 11:45 AM

PURPOSE: COPD is a systemic inflammatory disease. The role of yoga therapy in COPD is unclear. We investigated to see whether structured yoga training effects the levels of inflammatory markers, dyspnoea and quality of life in patients with stable COPD.

METHODS: 29 stable patients with COPD were recruited. Patients were taught yoga exercises by an instructor in a predesigned format including asanas ( physical postures), pranayama (breathing technique), kriyas (cleansing technique), meditation and shavasan (relaxation technique) for 1 hour duration twice a week for the first 4 weeks. For the next 8 weeks the sessions were fortnightly. The remaining sessions were done at home. Baseline evaluation included assessment of lung function, severity of dyspnoea [oxygen cost diagram, six minute walk test {6MWT}, MRC grade] ,quality of life, serum inflammatory markers (CRP, TNF-α, Il-6, Il-8) . Repeat assessment of all parameters was done at the end of 12 weeks of training.

RESULTS: Median serum levels of CRP, TNF- α, Il-6 and Il-8 at base line were 1.0(0.0-12.0) mg/dl, 0.00(0.0-566.0) pg/ml, 0.0(0.0-170.03) pg/ml and 0(0.0-1488.0) pg/ml respectively. Median levels of CRP, TNF- α, Il-6 and Il-8 after 12 weeks were 0.8(0.1-10.0) mg/dl, 0.0 (0-557.0) pg/ml, 0 (0.0-174) pg/ml and 0.0(0.0-1076.0)pg/ml respectively. Median values of 6MWT, Borg scale and VAS at baseline were 390.00(180.0-690.0) meters, 2.0(.5-7.0), 55.0(40.0-80.0) mm and after 12 weeks were 450.0(270.0-630.0) meters, .500(.0-4.0) 70.0(55.0-95.0) mm respectively. All these parameters showed significant improvement. The quality of life score showed significant improvement from baseline value of 50.97(8.58-82.80) to 31.44(1.53-78.61) at 12 weeks.

CONCLUSIONS: Yoga exercises resulted in improvement in pulmonary functions, 6MWT, Borg scale, severity of dyspnoea, quality of life and a decreased levels of CRP after 12 weeks. No significant change was found in the levels of Il-6, IL-8 and TNF-α.

CLINICAL IMPLICATIONS: Yoga is a simple, cost effective and a patient acceptable method to improve dyspnoea and quality of life in COPD. As COPD increases in developing countries this method of simple rehabilitation needs proper evaluation.

DISCLOSURE: The following authors have nothing to disclose: Sneh Arora, Randeep Guleria, Guresh Kumar, Shiv Lal Yadav, Anant Mohan

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