Sleep Disorders |

Short Sleep Duration Insomnia May Be Associated With Increased Cardiovascular Disease in Schizophrenics FREE TO VIEW

Terese Hammond, MD; Joleen Aguon, MD; Janet Sobell, PhD; Brooke Sklar, MA; Michele Pato, MD
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Keck Medical School of USC Division of Pulmonary Critical Care Sleep Medicine, Los Angeles, CA

Chest. 2013;144(4_MeetingAbstracts):996A. doi:10.1378/chest.1703315
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SESSION TITLE: Sleep Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Insomnia is highly prevalent amongst patients with mental illness and has been implicated as both a risk factor and marker of disease severity in various psychiatric diseases, including schizophrenia. Recent studies have delineated distinct subtypes of insomnia based on overall sleep duration, with the “short sleep duration” variant associated with increased risk of cardiovascular diseases such as hypertension, coronary heart disease and stroke in a community-based cohort. However, no previous study has examined this relationship in schizophrenic patients. We evaluated the association between short sleep duration insomnia and select cardiovascular diseases in schizophrenics.

METHODS: A total of 2,152 participants enrolled in the multi-center Genomic Psychiatric Cohort (GPC) self-reported their baseline sleep duration and medical comorbidities. In participants with schizophrenia or schizoaffective-depressed disorder, 1417 had symptoms of insomnia (mean age 42.4 years, 62% male, 55% non-white). This group was further stratified into “short sleep duration” insomnia, defined as sleep time ≤ six hours per night (n = 316) and normal sleep duration insomnia, defined as sleep time seven to nine hours per night, (n=989). Participates who reported greater than nine hours of sleep (n=112) were not included here. Chi square analysis was performed.

RESULTS: Of the 1417 patients with insomnia, those with short sleep duration insomnia self-reported significantly more coronary heart disease (n=44, OR 1.58; 95% CI 1.09-2.31; p <0.05), hypertension (n=127, OR 1.42; 95% CI 1.10-1.84; p < 0.05) and stroke (n=26, OR 2.54; 95% CI 1.54-4.33; p <0.05) when compared to those who self-reported a normal sleep duration.

CONCLUSIONS: Schizophrenics who self-reported insomnia symptoms and short sleep duration may have increased incidence of cardiovascular diseases such as hypertension, coronary heart disease and stroke. Further study to examine the strength of the association and possible confounders is warranted.

CLINICAL IMPLICATIONS: Short sleep duration insomnia may be a distinct and modifiable risk factor for cardiovascular diseases such as hypertension, coronary heart disease and stroke in schizophrenics.

DISCLOSURE: The following authors have nothing to disclose: Terese Hammond, Joleen Aguon, Janet Sobell, Brooke Sklar, Michele Pato

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