Lung Cancer |

Triggering Receptor Expressed in Myeloid Cells (TREM-1) in Human Non-small Cell Lung Cancer (NSCLC) FREE TO VIEW

Hiren Mehta, MD; Zhihong Yuan, PhD; K. Mohammed, PhD; N. Nasreen, PhD; Vipul Patel, MD; Peruvemba Sriram, MD; Ruxana Sadikot, MD
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University of Florida, Gainesville, FL

Chest. 2013;144(4_MeetingAbstracts):643A. doi:10.1378/chest.1703064
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SESSION TITLE: Biomarkers in Lung Cancer

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, October 27, 2013 at 10:45 AM - 11:45 AM

PURPOSE: It is increasingly recognized that interaction of cancer cells, macrophages, and inflammatory response in the tumor micro-environment may facilitate cancer cell invasion and metastasis. However the specific molecular mechanisms are not well defined. Triggering receptor expressed on myeloid cells 1 (TREM-1) is a member of the super immunoglobulin family expressed on a select group of monocyte macrophage and neutrophils. TREM-1 amplifies toll like receptor (TLR) induced inflammatory response. We have previously shown that TREM-1 accentuates inflammatory response by inhibiting apoptosis of macrophages thus prolonging their survival. Based on these data we hypothesize that TREM-1 expression in tumor associated macrophages (TAM) is an important regulator of lung cancer progression. To address this we determined the expression of TREM-1 in human NSCLC specimens.

METHODS: Tumor and normal lung specimens from patients who underwent surgical resection for NSCLC were obtained from clinical and translational research institute at University of Florida. TREM-1 expression was determined by using immunohistochemistry and confocal microscopy. Macrophage specificity was determined by CD68 staining. TREM-1 expression was also confirmed by quantitative real time polymerase chain reaction (RT-PCR) from tumor tissue.

RESULTS: Immunostaining and confocal microscopy showed that TREM-1 was highly expressed in macrophages in the tumor tissue as confirmed by CD68 staining. Tumor tissue showed an increase in TREM-1 mRNA expression. TREM-1 was not detected in macrophages from normal lung tissue.

CONCLUSIONS: Our data shows that TREM-1 is highly expressed in NSCLC and not detected in normal lung tissue. Expression of TREM-1 in tumors is specifically seen in TAM's. Thus expression of TREM-1 in tumors may play a key role in the biology and progression of NSCLC.

CLINICAL IMPLICATIONS: Detection of TREM-1 may serve as an important biomarker in lung cancer progression. Future studies are needed to define the role of modulation of TREM-1 in NSCLC.

DISCLOSURE: The following authors have nothing to disclose: Hiren Mehta, Zhihong Yuan, K. Mohammed, N. Nasreen, Vipul Patel, Peruvemba Sriram, Ruxana Sadikot

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