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Obstructive Lung Diseases |

Relationship Between Volumetric CT Metrics and Lung Volume Compartments in Patients With Chronic Obstructive Pulmonary Disease

JaeSeung Lee, MD; Sei Won Lee, MD; Jin Won Huh, MD; Yeon-Mok Oh, MD; Sang-Do Lee, MD
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Asan Medical Center, University of Ulsan, Seoul, Republic of Korea


Chest. 2013;144(4_MeetingAbstracts):690A. doi:10.1378/chest.1702147
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Abstract

SESSION TITLE: COPD Diagnosis & Evaluation Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: The aim of this study was to evaluate the relationship between volumetric CT metrics and lung volume compartments measured by body plethysmography in patients with chronic obstructive pulmonary disease (COPD).

METHODS: Data on a total of 156 patients with stable COPD from the Korean Obstructive Lung disease (KOLD) cohort were retrospectively analyzed. Volumetric CT was performed to quantify emphysema extent, air trapping, and large airway thickness. Lung volumes, including total lung capacity (TLC), vital capacity (VC), inspiratory capacity (IC), functional residual capacity (FRC) and residual volume (RV), were measured by body plethysmography. We examined the relationship between volumetric CT metrics and lung volume compartments.

RESULTS: Of the 156 included patients, 150 (96%) were male, the mean age was 66.2 (SD: 7.5) years, mean smoking history was 45.7 (25.1) pack-years, and mean post-bronchodilator FEV1 was 52.8 (15.7) % of predicted value. The full inspiratory lung volume (Vinsp) and full expiratory lung volume (Vexp) measured by volumetric CT were highly correlated with the TLC and FRC (R=0.769, p<0.001, R=0.800, p<0.001). However, the mean Vinsp and Vexp were significantly lower than the mean TLC and FRC (6.04 vs 6.59, p<0.001, and 4.20 vs 4.54, p<0.001). Simple correlation analysis showed that CT emphysema extent was significantly correlated with TLC (% predicted) (R=0.454, p<0.01), FRC (% predicted) (R=0.500, p<0.001), RV (% predicted) (R=0.412, p<0.001), and IC/TLC (%) (R=-0.445, p<0.001). CT air-trapping index was also significantly correlated with TLC (% predicted) (R=0.492 p<0.01), FRC (% predicted) (R=0.555, p<0.001), RV (% predicted) (R=0.473, p<0.001), and IC/TLC (%) (R=-0.571, p<0.001). However, airway wall thickness was only correlated with IC/TLC (%) (R=-0.212, p=0.008). Multiple linear regression analysis showed that CT emphysema index, air-trapping index and airway wall thickness had independent association with IC/TLC (%).

CONCLUSIONS: This study shows that volumetric CT metrics correlate relatively well with lung volume compartments measured by body plethysmography.

CLINICAL IMPLICATIONS: Volumetric CT metrics is useful for assessing the lung volume compartments in patients with COPD.

DISCLOSURE: The following authors have nothing to disclose: JaeSeung Lee, Sei Won Lee, Jin Won Huh, Yeon-Mok Oh, Sang-Do Lee

No Product/Research Disclosure Information


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