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Chest Infections |

The Efficacy of 23-Valent Pneumococcal Polysaccharide Vaccine in Preventing Pneumonia and Invasive Pneumococcal Disease in the Elderly Aged 75 Years and Older in Taiwan

Meng-Jer Hsieh, MD; Ying-Huang Tsai, MD; Chee-Jen Chang, PhD; Yu-Wen Wen, PhD; Han-Chung Hu, MD; Yen-Nan Chao, MD; Yhu-Chering Huang, PhD; Cheng-Ta Yang, MD; Chung-Chi Huang, MD
Author and Funding Information

Chang-Gung Memorial Hospital, Kwei-Hsang Hsiang, Taiwan


Chest. 2013;144(4_MeetingAbstracts):254A. doi:10.1378/chest.1701603
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Abstract

SESSION TITLE: Infections in Older Patients

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, October 27, 2013 at 04:15 PM - 05:15 PM

PURPOSE: A nationwide pneumococcal vaccination program in Taiwan provided 23-valent pneumococcal polysaccharide vaccines (PPV) and seasonal influenza vaccinations to persons aged 75 years and above in 2007 to 2009. The efficacy of these vaccines in 2010 was evaluated.

METHODS: Data were analyzed using the Taiwan National Health Insurance Research Database, cause of death database and invasive pneumococcal disease (IPD) notification file of the Taiwan Department of Health. The efficacy of PPV and influenza vaccine in the risk of hospitalization due to pneumonia, invasive pneumococcal disease, mortality due to pneumonia and all-cause mortality were evaluated using propensity score matching (PSM) followed by multivariate logistic regression method.

RESULTS: Among the 1,063,116 eligible persons, 46,451 (4.31%) had PPV alone, 203,298 (18.84%) had influenza vaccine alone, 271,806 (25.19%) had both vaccines and 557,400 (51.66%) had not been vaccinated. After PSM, there were 37,348 persons in each group. Those vaccinated with PPV alone or both vaccines had significantly lower risks of pneumonia hospitalization (OR 0.45 and 0.44), deaths due to pneumonia (OR 0.06 and 0.13) and all-cause mortality (OR 0.03 and 0.09) compared to those without PPV vaccination. There were significant lower risks for persons vaccinated with PPV in the development of IPD (OR 0.23). Additional influenza vaccinations had no additive protective effects in pneumonia hospitalization, IPD, deaths due to pneumonia or all-cause mortality.

CONCLUSIONS: Vaccination with PPV in persons aged 75 years and older was effective in reducing the risks of pneumonia hospitalization, IPD, all-cause mortality and deaths due to pneumonia.

CLINICAL IMPLICATIONS: PPV vaccination to the elderly aged 75 years and old had beneficial effects in reduction of pneumonia and invasive pneumococcal diseases.

DISCLOSURE: The following authors have nothing to disclose: Meng-Jer Hsieh, Ying-Huang Tsai, Chee-Jen Chang, Yu-Wen Wen, Han-Chung Hu, Yen-Nan Chao, Yhu-Chering Huang, Cheng-Ta Yang, Chung-Chi Huang

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