0
Chest Infections |

Diagnostic Role of Serum Adenosine Deaminase in Miliary Tuberculosis: Experience From a Tertiary Care Hospital in North India

Prasanta Mohapatra, MD; Deepak Aggarwal, MD; Rahul Katyal, MBBS; C. Prashanth, MBBS; Deepak Tekke, MBBS; Robin Gupta, MBBS; Kranti Garg, MD
Author and Funding Information

Government Medical College and Hospital, Chandigarh, India


Chest. 2013;144(4_MeetingAbstracts):264A. doi:10.1378/chest.1701356
Text Size: A A A
Published online

Abstract

SESSION TITLE: Respiratory Infections Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Miliary tuberculosis is a form of disseminated tuberculosis resulting from lymphohaematogenous spread of mycobacterium tuberculosis. Sputum for acid fast bacilli (AFB) is usually negative. Anti-tuberculosis treatment is given generally on presumptive basis. Radiologically many other diseases can mimic miliary tuberculosis.Pleural fluid adenosine deaminase (ADA) has established role in diagnosis of tubercular pleural effusion. So, serum ADA can be useful in contributing the diagnosis in the patients having miliary shadows in chest radiographs.

METHODS: This study was carried out to estimate the role of serum ADA in miliary tuberculosis and compare it with other diagnostic modalities. We assessed miliary tuberculosis patients diagnosed clinically and radiologically in the outpatient department. The patients after due consent had undergone eye checkup for choroid tubercles, sputum examination for AFB and blood examination for serum ADA by ADA assay kit (on autoanalyzer) and other routine investigations.

RESULTS: Of the 13 subjects(8 males,5 females),only two patients were AFB positive in their sputum. Five patients had choroid tubercles and all the patients had high serum ADA levels.The values of serum ADA were 52.61± 17.73 in miliary tuberculosis, 59.6±23.66 in patients having choroid tubercles,13.75 ±3. 35 in control and 28.8±6.40 in sputum AFB positive patients. All the miliary tuberculosis patients improved with routine anti-tubercular drugs.

CONCLUSIONS: The patients with miliary tuberculosis have raised serum ADA levels in comparision to healthy control and pulmonary tuberculosis. So higher ADA levels in miliary tuberculosis can be surrogate marker of diagnosis of miliary tuberculosis along with miliary shadow in chest radiograph where no definite diagnostic modality is available for confirming tuberculosis.

CLINICAL IMPLICATIONS: Serum ADA can be contributing in diagnosis of patients with miliary tuberculosis. The determination of serum ADA is rapid and cheap. After confirming the same in large multicentric trial, it can be of great value in diagnosis of miliary tuberculosis.

DISCLOSURE: The following authors have nothing to disclose: Prasanta Mohapatra, Deepak Aggarwal, Rahul Katyal, C. Prashanth, Deepak Tekke, Robin Gupta, Kranti Garg

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543