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Utility of N-Terminal Pro-B-Type Natriuretic Peptide in Patients Admitted to Intensive Care Unit FREE TO VIEW

Heayon Lee, MD; Chin Kook Rhee, MD; So Yeon Lim, MD; Gee Young Suh, MD; Shin Ok Koh, MD; Won Il Choi, MD; Young Joo Lee, MD; Gyu Rak Chon, MD; Je Hyeong Kim, MD; Jae Yeol Kim, MD; Jaemin Lim, MD; Sunghoon Park, MD; Ho Cheol Kim, MD; Jin Hwa Lee, MD; Ji Hyun Lee, MD; Yoonsuck Koh, MD; Seok Chan Kim, MD
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Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea

Chest. 2013;144(4_MeetingAbstracts):546A. doi:10.1378/chest.1701262
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SESSION TITLE: Outcomes/Quality Control Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor for patients who are admitted to the intensive care unit (ICU) is not fully established yet. This study is aimed to determine whether NT-pro-BNP predicts ICU mortality in a multicenter cohort of critically ill patients.

METHODS: A total of 1440 patients admitted to 22 ICUs (medical = 14, surgical = 6, multidisciplinary = 2) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were analyzed. Patient data including NT-pro-BNP and Simplified Acute Physiology Score (SAPS) 3 score were recorded prospectively in a web-based database.

RESULTS: Data are given as median (range). The age was 64 (53-73) and 906 (62.9 %) patients were male. The level of NT-pro-BNP was 341 (104-1,637) pg/mL and SAPS 3 score was 57 (47-69). ICU mortality was 18.9 % and hospital mortality was 24.5 %. Hospital survivors had significantly lower NT-pro-BNP values than nonsurvivors (245 [82-1,053] vs. 875 [241-5,000] pg/mL, survivors vs. nonsurvivors, respectively, p < 0.001). In a logistic regression model SAPS 3 score and NT-pro-BNP were independent factors for predicting ICU mortality.

CONCLUSIONS: NT-pro-BNP is more elevated in nonsurvivors in a multicenter cohort of critically ill patients.

CLINICAL IMPLICATIONS: It is an independent predictor of ICU mortality.

DISCLOSURE: The following authors have nothing to disclose: Heayon Lee, Chin Kook Rhee, So Yeon Lim, Gee Young Suh, Shin Ok Koh, Won Il Choi, Young Joo Lee, Gyu Rak Chon, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Sunghoon Park, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Yoonsuck Koh, Seok Chan Kim

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