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Allergy and Airway |

Exhaled Nitric Oxide in Diagnosis and Management of Respiratory Diseases

Eugerta Dilka, MD; Eritian Tashi, MD; Armela Cuko, MD; Jeta Beli, PhD; Elenka Shehu, PhD; Roland Kore, MD; Dhimitraq Argjiri, MD; Arben Tanka, MD; Edlira Ndreu, MD; Esmeralda Nushi, MD; Perlat Kapisyzi, PhD
Author and Funding Information

Faculty of Medicine, Tirana, Albania


Chest. 2013;144(4_MeetingAbstracts):69A. doi:10.1378/chest.1700037
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Abstract

SESSION TITLE: Asthma Diagnosis & Evaluation

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Tuesday, October 29, 2013 at 02:45 PM - 04:15 PM

PURPOSE: To study the values of FENO in some of respiratory diseases and the relationship of the value of FENO with desease stage and pulmonary function tests

METHODS: This was a prospective study. FeNO has been measured in 111 patients : 41 patients with a diagnosis of asthma , 3 with GERD, 19 with bronchectasia, 11 with sarcoidosis, 23 with COPD , 14 with secondary Pulmonary Hipertension. FeNO was measured by chemoluminescence using an online nitric oxide monitor (NIOX MINO; Aerocrine AB, Solna, Sweden), according to the 1999 American Thoracic Society (ATS) guidelines and consistent with the ATS guidelines published in 2005. We used for independent samples t test and ANOVA for comparison of average values FENO according to diagnosis and respiratory tests. Significance was defined as a p value of < 0.05. Statistical tests are two-sided.

RESULTS: The mean FENO for patients with asthma was 30.5pp ±30.7SD with range 5 - 124. p=0.003. The mean FENO is higher in moderate stage 91ppb, intermittente stage 80.5ppb, severe 63ppb and mild stage 60ppb.The mean of FENO in the patients with asthma with normal value of IgE and high value of IgE were 15.8 ±13.4SD and 64.9 ±28.1SD respectively. p<0.01.The mean of FENO in the diseases with obstruction of the small airway was 18.2±20.4SD with range 5 - 63.The mean of FENO in GERD with obstruction of the small airway was 6.7 ±2.1SD , the mean of FENO in patients with asthma with obstruction of the small airway was 27.0 ±25.0SD.p=0.2. (the difference is very high but it has not brought significant change due to the small size of the sample) ., The mean of FENO in COPD was higher in the second stage (41) than the third stage (13.5) and the fourth stage ( 7.7) The mean FENO in patients with secondary pulmonary hypertension was 12.2 ±5.6D with range 5 - 20.

CONCLUSIONS: The value of FeNO in astma is not correlated with the values of FEV1 but with the activity of eosinophilc inflammation and atopy. There was significant change between the mean of FENO to the stages of COPD. There was negative moderate correlation between the value of FENO and PSAP.

CLINICAL IMPLICATIONS: The use of FeNO in daily practice is very useful in differential diagnosis of obstructive bronchial diseases,in determing of the severety of inflammation and pulmonary hypertention.

DISCLOSURE: The following authors have nothing to disclose: Eugerta Dilka, Eritian Tashi, Armela Cuko, Jeta Beli, Elenka Shehu, Roland Kore, Dhimitraq Argjiri, Arben Tanka, Edlira Ndreu, Esmeralda Nushi, Perlat Kapisyzi

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