Obstructive Lung Diseases |

Serum Prealbumin Is a Useful Marker of Inflammation and Monitoring Tool in Patients With AECOPD FREE TO VIEW

Kriti Upadhyay, MA; Arvind Uniyal, MA; Randeep Guleria, DM; Dharmender Prasad, MD; Alpana Sharma, PhD; R. Pandey, PhD; Anant Mohan, MD
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All India Institute of Medical Sciences, New Delhi, India

Chest. 2013;144(4_MeetingAbstracts):708A. doi:10.1378/chest.1699558
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SESSION TITLE: COPD Diagnosis & Evaluation Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: To study the change in levels of inflammatory and nutritional markers in AECOPD and correlate them with clinical and laboratory indices of recovery.

METHODS: Serum levels of Leptin, Pre-albumin and Tumor Necrosis Factor α (TNF- α) were estimated in hospitalized AECOPD patients within 48 hours of hospitalized and pre discharge.

RESULTS: 82 patients were evaluated with a mean (SD) age of 61.6 (10.1) years. The median (range) hospital stay and pack years of smoking were 13 (1-77) days and 15 (0-80) respectively. The mean (SD) duration of COPD and duration of current symptoms were 9.6 (1.8) and 9.1(8.6) days respectively. 46 patients (59%) required ventilation with a median (range) duration of 6 (1-34) days. The mean (SD) APACHE score and BMI were 17.6 (5.2) and 23.4 (15.3) respectively. Baseline serum leptin, pre-albumin and TNF- α levels were elevated. Significant improvement in leptin and pre-albumin were observed between admission and hospital discharge. Moreover, significant improvement occurred in respiratory rate, dyspnea, PCO2, hemoglobin, TLC, urea, creatinine, potassium, albumin, and SGPT. Change in Pre-albumin levels correlated significantly with duration of ventilation and duration of hospital stay.

CONCLUSIONS: Serum Prealbumin is a potentially useful marker for monitoring response in AECOPD. The role of Leptin and TNF- α requires further evaluation.

CLINICAL IMPLICATIONS: Serum Pre-albumin may be simple routinely performed investigation to monitor the clinical course of AECOPD

DISCLOSURE: The following authors have nothing to disclose: Kriti Upadhyay, Arvind Uniyal, Randeep Guleria, Dharmender Prasad, Alpana Sharma, R. Pandey, Anant Mohan

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