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Allergy and Airway |

Impact of Asthma Severity Over Peripheral Motor Nerve Functions

Dipti Agarwal, MD; Sushma Sood, MD; Prem Parkash Gupta, MD
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Dept. of Physiology, PGIMS, Rohtak, India


Chest. 2013;144(4_MeetingAbstracts):70A. doi:10.1378/chest.1698588
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Abstract

SESSION TITLE: Asthma Diagnosis & Evaluation

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Tuesday, October 29, 2013 at 02:45 PM - 04:15 PM

PURPOSE: A comparative assessment of peripheral motor nerves functions in asthma patients organized to two groups according to spirometric severity; and to evaluate for correlation(s) of patients' characteristics and spirometric indices with peripheral motor nerves functions in these patients.

METHODS: We included 60 chronic persistent stable asthma patients (40 females and 20 males) diagnosed as per GINA guidelines. They were organized to two groups: 30 patients with FEV1/FVC ratio > 70% (Group 1) and 30 patients with FEV1/FVC ratio ≤70% (Group 2). Electrophysiological study was carried out to assess amplitude, latency and conduction velocity of four motor nerves - median nerve, ulnar nerve, common peroneal nerve and tibial nerve. Significance of difference between identical parameters of two groups was analyzed. Correlations of patients` characteristics and spirometric indices with the nerve function parameters were also analyzed.

RESULTS: There was no difference between groups regarding age (28.47±9.24 year vs. 29.67±4.66 year; p value=0.528) and height (p value= 0.738). Group 2 patients had significantly more duration of illness (11.23 ± 3.32 year vs. 5.57 ± 3.18 year) and lower FEV1 (2.130 ± 0.381 L vs. 2.856 ± 0.427 L), lower PEFR (4.879 ± 0.576 L/s vs. 5.988 ± 0.820 L/s). In Group 2, conduction velocities of all nerves were significantly decreased, but the latency of median motor nerve only was prolonged significantly. The decreased in amplitudes of motor nerves in Group 2 were not statistically significant. Duration of illness, FEV1 and PEFR were significantly correlated with nerves functions parameters.

CONCLUSIONS: We found that asthma patients with more disease severity had decreased conduction velocities of all studied motor nerves and increased latency of median motor nerve. Duration of illness, FEV1 and FVC were correlated with peripheral motor nerves functions.

CLINICAL IMPLICATIONS: As peripheral motor nerves are often not suspected to be involved in asthma patients, the peripheral motor nerve dysfunctions in many of them remain under diagnosed and may affect the quality of life in many of these patients.

DISCLOSURE: The following authors have nothing to disclose: Dipti Agarwal, Sushma Sood, Prem Parkash Gupta

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